A number of new positive allosteric modulators (PAMs) have been reported that enhance
responses of neuronal alpha7 and alpha4beta2 nicotinic acetylcholine receptor subtypes to …

We performed a hierarchical structure-based virtual screening utilizing a comparative model
of the human α4β2 neuronal nicotinic acetylcholine receptor (nAChR) extracellular domain …

Allosteric modulation of ligand-gated ion channels has been intensively studied in the past
three decades and is now an established strategy to control receptor function in numerous …

Subtype selective molecules for α4β2 neuronal nicotinic acetylcholine receptors (nAChRs)
have been sought as novel therapeutics for nicotine cessation. α4β2 nAChRs have been …

Introduction: Snake venom is a combination of various proteins and peptides that cause
diverse biological effects on multiple organ systems. In elapid venom, three-finger toxins are …

Nicotinic acetylcholine receptors (nAChRs) have been implicated by behavioral, anatomical
and pharmacological studies, in a wide range of neurological pathways and disorders and …

The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability throughout the
nervous system by acting on the cys-loop cation-conducting ligand-gated nicotinic ACh …

Nicotinic acetylcholine receptors (nAChRs) are the targets for the endogenous
neurotransmitter acetylcholine and represent a diverse family of ligand-gated ion channels …

The Commission has established a priority list of 15 additives contained in cigarettes and
roll-your-own tobacco subject to enhanced reporting obligations, based on a scientific …

Alzheimer's disease Alpha conotoxin GID Molecular Dynamics Simulation Nicotinic
Acetylcholine Receptor Calcium Neuro-degenerative disorde Computational Biology …