Review of the endocannabinoid system
The endocannabinoid system (ECS) is a widespread neuromodulatory network involved in
the developing central nervous system as well as playing a major role in tuning many …
the developing central nervous system as well as playing a major role in tuning many …
Cannabinoid receptors and the endocannabinoid system: signaling and function in the central nervous system
S Zou, U Kumar - International journal of molecular sciences, 2018 - mdpi.com
The biological effects of cannabinoids, the major constituents of the ancient medicinal plant
Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled …
Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled …
Activation and signaling mechanism revealed by cannabinoid receptor-Gi complex structures
T Hua, X Li, L Wu, C Iliopoulos-Tsoutsouvas, Y Wang… - Cell, 2020 - cell.com
Human endocannabinoid systems modulate multiple physiological processes mainly
through the activation of cannabinoid receptors CB1 and CB2. Their high sequence …
through the activation of cannabinoid receptors CB1 and CB2. Their high sequence …
Structure of a signaling cannabinoid receptor 1-G protein complex
Cannabis elicits its mood-enhancing and analgesic effects through the cannabinoid receptor
1 (CB1), a G protein-coupled receptor (GPCR) that signals primarily through the adenylyl …
1 (CB1), a G protein-coupled receptor (GPCR) that signals primarily through the adenylyl …
From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology
A Ligresti, L De Petrocellis… - Physiological …, 2016 - journals.physiology.org
Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …
CB1 receptor signaling in the brain: extracting specificity from ubiquity
Endocannabinoids (eCBs) are amongst the most ubiquitous signaling molecules in the
nervous system. Over the past few decades, observations based on a large volume of work …
nervous system. Over the past few decades, observations based on a large volume of work …
Cannabinoid receptors in the central nervous system: their signaling and roles in disease
DA Kendall, GA Yudowski - Frontiers in cellular neuroscience, 2017 - frontiersin.org
The identification and cloning of the two major cannabinoid (CB1 and CB2) receptors
together with the discovery of their endogenous ligands in the late 80s and early 90s …
together with the discovery of their endogenous ligands in the late 80s and early 90s …
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB1 and CB2
RG Pertwee, AC Howlett, ME Abood… - Pharmacological …, 2010 - ASPET
There are at least two types of cannabinoid receptors (CB1 and CB2). Ligands activating
these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ9 …
these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ9 …
[HTML][HTML] Cannabinoids and epilepsy
Cannabis has been used for centuries to treat seizures. Recent anecdotal reports,
accumulating animal model data, and mechanistic insights have raised interest in cannabis …
accumulating animal model data, and mechanistic insights have raised interest in cannabis …
International Union of Pharmacology. XXVII. Classification of cannabinoid receptors
AC Howlett, F Barth, TI Bonner, G Cabral… - Pharmacological …, 2002 - ASPET
Two types of cannabinoid receptor have been discovered so far, CB1 (2.1: CBD: 1: CB1:),
cloned in 1990, and CB2 (2.1: CBD: 2: CB2:), cloned in 1993. Distinction between these …
cloned in 1990, and CB2 (2.1: CBD: 2: CB2:), cloned in 1993. Distinction between these …