Adrenal insufficiency is the clinical manifestation of deficient production or action of
glucocorticoids, with or without deficiency also in mineralocorticoids and adrenal androgens …

Objective Surgery is a stressor that can be categorized by duration and severity and induces
a systemic stress response that includes increased adrenal cortisol production. However …

Context Patients with adrenal insufficiency require increased hydrocortisone cover during
major stress to avoid a life-threatening adrenal crisis. However, current treatment …

OBJECTIVE: To evaluate the effect of bed rest with music on the first postoperative day to
decrease stress for patients who have undergone heart surgery. METHODS: A repeated …

BACKGROUND: During stress, vasopressin is a potent synergistic factor of CRH as a
hypothalamic stimulator of the HPA axis. The measurements of CRH and vasopressin levels …

Context: Adrenal failure secondary to hypothalamo-pituitary disease is a common clinical
problem which has serious repercussions. It is essential to perform validated diagnostic …

Routine assessment of the hypothalamic–pituitary–adrenal axis relies on the measurement
of total serum cortisol levels. However, most cortisol in serum is bound to corticosteroid …

Chronic environmental stress can profoundly impact cell and body function. Although the
underlying mechanisms are poorly understood, epigenetics has emerged as a key link …

If used in the proper setting, serial measurements of diagnostic biomarkers may allow
treatments to be adjusted at an early stage in patients with severe infections. This may …

The anterior pituitary gland has the ability to respond to complex signals derived from central
and peripheral systems. Perception of these signals and their integration are mediated by …