Behavioral variant frontotemporal dementia (bvFTD) is the second leading cognitive
disorder caused by neurodegeneration in patients under 65 years of age. Characterized by …

Frontotemporal dementias are a clinically, neuroanatomically, and pathologically diverse
group of diseases that collectively constitute an important cause of young-onset dementia …

Homozygous or heterozygous mutations in the GRN gene, encoding progranulin (PGRN),
cause neuronal ceroid lipofuscinosis (NCL) or frontotemporal dementia (FTD), respectively …

Frontotemporal dementia refers to a group of neurodegenerative disorders characterized by
behaviour and language alterations and focal brain atrophy. Amyotrophic lateral sclerosis is …

In this review, the authors explored the clinical features of frontotemporal dementia (FTD),
focusing on treatment. The clinical features of FTD are unique, with disinhibition, apathy …

Frontotemporal dementia and amyotrophic lateral sclerosis are clinically and pathologically
overlapping disorders with shared genetic causes. We previously identified a disease locus …

Haploinsufficiency of progranulin (PGRN) due to mutations in the granulin (GRN) gene
causes frontotemporal lobar degeneration (FTLD), and complete loss of PGRN leads to a …

The small GTPases from the Ras superfamily play crucial roles in basic cellular processes
during practically the entire process of neurodevelopment, including neurogenesis …

Nucleocytoplasmic transport (NCT) across the nuclear envelope is precisely regulated in
eukaryotic cells, and it plays critical roles in maintenance of cellular homeostasis …

Frontotemporal dementia (FTD) is a neurodegenerative disease, leading to behavioral
changes and language difficulties. Heterozygous loss-of-function mutations in progranulin …