Background Behavioral variant frontotemporal dementia (bvFTD) is a common form of
younger-onset dementia with a proportion of cases overlapping pathologically and …

Frontotemporal lobar degeneration with TPD-43-immunoreactive pathology (FTLD-TDP) is
subclassified based on the type and cortical laminar distribution of neuronal inclusions. The …

Aggregation of hyperphosphorylated TDP-43 is the hallmark pathological feature of the most
common molecular form of frontotemporal lobar degeneration (FTLD–TDP) and in the vast …

Progranulin (PGRN) haploinsufficiency associated with loss-of-function mutations in the
granulin gene causes frontotemporal dementia (FTD). This suggests that increasing PGRN …

A GGGGCC hexanucleotide repeat expansion in the C9ORF72 gene has been identified as
the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal …

The genetic underpinnings of the most common adult-onset neurodegenerative disorders
(AOND) are complex in majority of the cases. In some families, however, the disease can be …

Parkin and PINK1 are key regulators of mitophagy, an autophagic pathway for selective
elimination of dysfunctional mitochondria. To this date, parkin depletion has been …

Frontotemporal dementia is a group of early onset dementia syndromes linked to underlying
frontotemporal lobar degeneration (FTLD) pathology that can be classified based on the …

Tauopathies are a heterogenous group of neurodegenerative disorders characterized by tau
aggregation in the brain. In a subset of tauopathies, rare mutations in the MAPT gene, which …

Dementia—a syndrome affecting human cognition—is a major public health concern given
to its rising prevalence worldwide. Though multiple research studies have analyzed …