Muscle and bone interact via physical forces and secreted osteokines and myokines.
Physical forces are generated through gravity, locomotion, exercise, and external devices …

Chronic psychological stress affects many body systems, including the skeleton, through
various mechanisms. This review aims to provide an overview of the factors mediating the …

Histone modification critically contributes to the epigenetic control of gene expression by
changing the configuration of chromatin and modifying the access of transcription factors to …

MiR-1908 is a miRNA located in the intron of the fatty acid desaturase 1 (FADS1) gene. The
expression level of miR-1908 is abnormal in many diseases such as cancer. miR-1908 can …

The rising incidence of bone pathologies such as osteoporosis and osteoarthritis is
negatively affecting the functional status of millions of patients worldwide. The genetic …

The availability of large human datasets for genome-wide association studies (GWAS) and
the advancement of sequencing technologies have boosted the identification of genetic …

Within the last decade epigenetics has emerged as fundamental regulator of numerous
cellular processes, including those orchestrating embryonic and fetal development. As such …

Osteoporosis is a disease with complex etiology where the genetic factors may account for
as much as 50–85% of the risk of its development in postmenopausal women. The …

Long noncoding RNAs (lncRNAs) contribute toward regulating gene expression and cell
differentiation and may be involved in the pathogenesis of several diseases. The objective of …

Osteoporosis (OP) is a multifactorial disorder in which environmental factors along with
genetic variants and epigenetic mechanisms have been implicated. Long non-coding RNAs …