BRAD V3. 0: an upgraded Brassicaceae database

H Chen, T Wang, X He, X Cai, R Lin… - Nucleic Acids …, 2022 - academic.oup.com
Abstract The Brassicaceae Database (BRAD version 3.0, BRAD V3. 0; http://brassicadb. cn)
has evolved from the former Brassica Database (BRAD V2. 0), and represents an important …

Machine learning in enzyme engineering

S Mazurenko, Z Prokop, J Damborsky - ACS Catalysis, 2019 - ACS Publications
Enzyme engineering plays a central role in developing efficient biocatalysts for
biotechnology, biomedicine, and life sciences. Apart from classical rational design and …

The Taxus genome provides insights into paclitaxel biosynthesis

X Xiong, J Gou, Q Liao, Y Li, Q Zhou, G Bi, C Li, R Du… - Nature Plants, 2021 - nature.com
The ancient gymnosperm genus Taxus is the exclusive source of the anticancer drug
paclitaxel, yet no reference genome sequences are available for comprehensively …

The genome of oil-Camellia and population genomics analysis provide insights into seed oil domestication

P Lin, K Wang, Y Wang, Z Hu, C Yan, H Huang, X Ma… - Genome biology, 2022 - Springer
Background As a perennial crop, oil-Camellia possesses a long domestication history and
produces high-quality seed oil that is beneficial to human health. Camellia oleifera Abel. is a …

Anthoceros genomes illuminate the origin of land plants and the unique biology of hornworts

FW Li, T Nishiyama, M Waller, E Frangedakis, J Keller… - Nature plants, 2020 - nature.com
Hornworts comprise a bryophyte lineage that diverged from other extant land plants> 400
million years ago and bears unique biological features, including a distinct sporophyte …

Intracellular pathways for lignin catabolism in white-rot fungi

C Del Cerro, E Erickson, T Dong… - Proceedings of the …, 2021 - National Acad Sciences
Lignin is a biopolymer found in plant cell walls that accounts for 30% of the organic carbon
in the biosphere. White-rot fungi (WRF) are considered the most efficient organisms at …

Systematic exploration of Escherichia coli phage–host interactions with the BASEL phage collection

E Maffei, A Shaidullina, M Burkolter, Y Heyer… - PLoS …, 2021 - journals.plos.org
Bacteriophages, the viruses infecting bacteria, hold great potential for the treatment of
multidrug-resistant bacterial infections and other applications due to their unparalleled …

OrthoDB in 2020: evolutionary and functional annotations of orthologs

EM Zdobnov, D Kuznetsov, F Tegenfeldt… - Nucleic acids …, 2021 - academic.oup.com
OrthoDB provides evolutionary and functional annotations of orthologs, inferred for a vast
number of available organisms. OrthoDB is leading in the coverage and genomic diversity …

Biological plasticity rescues target activity in CRISPR knock outs

AH Smits, F Ziebell, G Joberty, N Zinn, WF Mueller… - Nature …, 2019 - nature.com
Gene knock outs (KOs) are efficiently engineered through CRISPR–Cas9-induced frameshift
mutations. While the efficiency of DNA editing is readily verified by DNA sequencing, a …

Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways

MJ Pichler, C Yamada, B Shuoker… - Nature …, 2020 - nature.com
The early life human gut microbiota exerts life-long health effects on the host, but the
mechanisms underpinning its assembly remain elusive. Particularly, the early colonization of …