DEEPScreen: high performance drug–target interaction prediction with convolutional neural networks using 2-D structural compound representations
The identification of physical interactions between drug candidate compounds and target
biomolecules is an important process in drug discovery. Since conventional screening …
biomolecules is an important process in drug discovery. Since conventional screening …
[HTML][HTML] EukProt: a database of genome-scale predicted proteins across the diversity of eukaryotes
DJ Richter, C Berney, JFH Strassert… - Peer Community …, 2022 - peercommunityjournal.org
EukProt is a database of published and publicly available predicted protein sets selected to
represent the breadth of eukaryotic diversity, currently including 993 species from all major …
represent the breadth of eukaryotic diversity, currently including 993 species from all major …
The virota and its transkingdom interactions in the healthy infant gut
Virome and 16/18S analyses were performed on 304 longitudinal fecal samples of eight
infants. The gut virota—the collection of all viruses present in the gut—was dominated by …
infants. The gut virota—the collection of all viruses present in the gut—was dominated by …
SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative
agent of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by …
agent of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by …
The impact of genetic diversity on gene essentiality within the Escherichia coli species
F Rousset, J Cabezas-Caballero, F Piastra-Facon… - Nature …, 2021 - nature.com
Bacteria from the same species can differ widely in their gene content. In Escherichia coli,
the set of genes shared by all strains, known as the core genome, represents about half the …
the set of genes shared by all strains, known as the core genome, represents about half the …
Potential virus-mediated nitrogen cycling in oxygen-depleted oceanic waters
Viruses play an important role in the ecology and biogeochemistry of marine ecosystems.
Beyond mortality and gene transfer, viruses can reprogram microbial metabolism during …
Beyond mortality and gene transfer, viruses can reprogram microbial metabolism during …
Wikidata as a knowledge graph for the life sciences
A Waagmeester, G Stupp, S Burgstaller-Muehlbacher… - Elife, 2020 - elifesciences.org
Wikidata is a community-maintained knowledge base that has been assembled from
repositories in the fields of genomics, proteomics, genetic variants, pathways, chemical …
repositories in the fields of genomics, proteomics, genetic variants, pathways, chemical …
[HTML][HTML] Furin cleavage sites naturally occur in coronaviruses
Y Wu, S Zhao - Stem cell research, 2021 - Elsevier
The spike protein is a focused target of COVID-19, a pandemic caused by SARS-CoV-2. A
12-nt insertion at S1/S2 in the spike coding sequence yields a furin cleavage site, which …
12-nt insertion at S1/S2 in the spike coding sequence yields a furin cleavage site, which …
Plant genome sequences: past, present, future
PJ Kersey - Current opinion in plant biology, 2019 - Elsevier
Highlights•Almost 600 complete plant genome assemblies are now available in public
repositories.•New sequencing technologies are producing genome assemblies of …
repositories.•New sequencing technologies are producing genome assemblies of …
Best practices on the differential expression analysis of multi-species RNA-seq
Advances in transcriptome sequencing allow for simultaneous interrogation of differentially
expressed genes from multiple species originating from a single RNA sample, termed dual …
expressed genes from multiple species originating from a single RNA sample, termed dual …