Ethnopharmacological relevance Rheumatoid arthritis (RA) is a chronic inflammatory
autoimmune disease influenced by diverse endogenous and exogenous factors. It is …

Control of excessive mitochondrial oxidative stress could provide new targets for both
preventive and therapeutic interventions in the treatment of chronic inflammation or any …

Background Cardiac fibrosis is a major structural change observed in the heart of patients
with type 2 diabetes mellitus (T2DM), ultimately resulting in heart failure (HF). Suppression …

Rheumatoid arthritis (RA) is among the most prevalent forms of autoimmunity.
Gentiopicroside (Gent) is an iridoid glucoside derived from the Gentiana Macrophylla Pall …

Gentianae Radix et Rhizoma is a medical plant that is widely cultivated in China, North
Korea, Japan, and Russia, and gentiopicroside is one of its major active compounds. In this …

Acute gouty arthritis is a self-limiting inflammatory disease resulting from the deposition of
monosodium urate (MSU) crystals. It has been shown that Gentiopicroside (GPS) possesses …

Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation of
keratinocytes and expression of pro-inflammatory cytokines in the epidermis. New biological …

Background: Excessive ethanol consumption results in gastric mucosa damage, which could
further develop into chronic gastritis, peptic ulcer, and gastric cancer in humans …

Allergic asthma is a common airway inflammatory disorder with increasing morbidity and
mortality worldwide. Gentiopicroside (GPS) is a secoiridoid glycoside compound that …

Aims This study aimed to examine whether gentiopicroside (GPS) could exert
hepatoprotective effects on leflunomide (LEF)-and/or methotrexate (MTX)-treated arthritic …