Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets
A Mushtaq, P Wu, MM Naseer - Pharmacology & Therapeutics, 2023 - Elsevier
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic …
S El-Kalyoubi, MM Khalifa, MT Abo-Elfadl… - Journal of enzyme …, 2023 - Taylor & Francis
A new wave of dual Topo I/II inhibitors was designed and synthesised via the hybridisation
of spirooxindoles and pyrimidines. In situ selenium nanoparticles (SeNPs) for some …
of spirooxindoles and pyrimidines. In situ selenium nanoparticles (SeNPs) for some …
Rational design and eco-friendly one-pot multicomponent synthesis of novel ethylidenehydrazineylthiazol-4 (5H)-ones as potential apoptotic inducers targeting wild …
A novel series of ethylidenehydrazineylthiazol-4 (5H)-ones were synthesized using various
eco-friendly one-pot multicomponent synthetic techniques. The anticancer activity of …
eco-friendly one-pot multicomponent synthetic techniques. The anticancer activity of …
A novel class of pyrazole analogues as Aurora kinase a inhibitor: design, synthesis, and anticancer evaluation
Pyrazole, as a small molecule, was discovered for higher cytotoxicity and affinity towards
Aurora-A kinase. Based on these facts, a novel pyrazole substituted at the 4 th position was …
Aurora-A kinase. Based on these facts, a novel pyrazole substituted at the 4 th position was …
Synthesis, Characterizations, and Quantum Chemical Investigations on Imidazo[1,2-a]pyrimidine-Schiff Base Derivative: (E)-2-Phenyl-N-(thiophen-2-ylmethylene)imidazo[1,2 …
M Azzouzi, O Azougagh, AA Ouchaoui, SE El Hadad… - ACS …, 2023 - ACS Publications
In this study,(E)-2-phenyl-N-(thiophen-2-ylmethylene) imidazo [1, 2-a] pyrimidin-3-amine (3)
is synthesized, and detailed spectral characterizations using 1H NMR, 13C NMR, mass, and …
is synthesized, and detailed spectral characterizations using 1H NMR, 13C NMR, mass, and …
Some pyrimidohexahydroquinoline candidates: synthesis, DFT, cytotoxic activity evaluation, molecular docking, and in silico studies
SK Ramadan, HSM Abd-Rabboh, AAA Hafez… - RSC …, 2024 - pubs.rsc.org
Some hexahydroquinoline candidates were prepared by reacting 2-amino-3-cyano-1-
cyclohexylhexahydroquinoline with oxalyl chloride and triethyl orthoformate. The …
cyclohexylhexahydroquinoline with oxalyl chloride and triethyl orthoformate. The …
Design and synthesis of novel pyrazolopyrimidine candidates as promising EGFR-T790M inhibitors and apoptosis inducers
Aim: Our objective was to design and synthesize a new range of pyrazolopyrimidines while
maintaining the key pharmacophoric features of EGFR tyrosine kinase inhibitors. Materials & …
maintaining the key pharmacophoric features of EGFR tyrosine kinase inhibitors. Materials & …
Synthesis, toxicological and in silico evaluation of novel spiro pyrimidines against Culex pipiens L. referring to chitinase enzyme
EM Abbass, AK Ali, AF El-Farargy… - Scientific Reports, 2024 - nature.com
The exponential development of resistance to conventional chemical insecticides adds
another important motive for the creation of novel insecticidal active agents. One of the keys …
another important motive for the creation of novel insecticidal active agents. One of the keys …
Design, synthesis and evaluation of dihydro-1H-indene derivatives as novel tubulin polymerisation inhibitors with anti-angiogenic and antitumor potency
S Xu, Y Sun, P Wang, Y Tan, L Shi… - Journal of Enzyme …, 2023 - Taylor & Francis
Angiogenesis plays an important role in tumour generation and progression, which is used
to supply nutrients and metastasis. Herein, a series of novel dihydro-1 H-indene derivatives …
to supply nutrients and metastasis. Herein, a series of novel dihydro-1 H-indene derivatives …
Structural and molecular insights from dual inhibitors of EGFR and VEGFR2 as a strategy to improve the efficacy of cancer therapy
K Budipramana, F Sangande - Chemical Biology & Drug …, 2024 - Wiley Online Library
Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor 2 (VEGFR2)
are known as valid targets for cancer therapy. Overexpression of EGFR induces …
are known as valid targets for cancer therapy. Overexpression of EGFR induces …