Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Natural medicines of targeted rheumatoid arthritis and its action mechanism

X Liu, Z Wang, H Qian, W Tao, Y Zhang, C Hu… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease involving joints, with clinical
manifestations of joint inflammation, bone damage and cartilage destruction, joint …

Safety profile of upadacitinib over 15 000 patient-years across rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and atopic dermatitis

GR Burmester, SB Cohen, KL Winthrop, P Nash… - RMD open, 2023 - rmdopen.bmj.com
Objective To evaluate the long-term safety profile for upadacitinib across rheumatoid arthritis
(RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS) and atopic dermatitis (AD) …

The application of Aptamer in biomarker discovery

Y Li, WW Tam, Y Yu, Z Zhuo, Z Xue, C Tsang, X Qiao… - Biomarker …, 2023 - Springer
Biomarkers are detectable molecules that can reflect specific physiological states of cells,
organs, and organisms and therefore be regarded as indicators for specific diseases. And …

Research progress of single-cell transcriptome sequencing in autoimmune diseases and autoinflammatory disease: A review

L Zeng, K Yang, T Zhang, X Zhu, W Hao, H Chen… - Journal of …, 2022 - Elsevier
Autoimmunity refers to the phenomenon that the body's immune system produces antibodies
or sensitized lymphocytes to its own tissues to cause an immune response. Immune …

6-Shogaol inhibits the proliferation, apoptosis, and migration of rheumatoid arthritis fibroblast-like synoviocytes via the PI3K/AKT/NF-κB pathway

N Li, X Li, L Deng, H Yang, Z Gong, Q Wang, D Pan… - Phytomedicine, 2023 - Elsevier
Abstract Background Fibroblast-like synoviocytes (FLSs) are essential for joint destruction in
rheumatoid arthritis (RA). 6-Shogaol, a phenolic extract isolated from ginger, has been found …

[HTML][HTML] Efficacy and safety of total glucosides of paeony in the treatment of 5 types of inflammatory arthritis: a systematic review and meta-analysis

K Yang, L Zeng, Z Long, Q He, W Xiang, A Ge… - Pharmacological …, 2023 - Elsevier
Objective To evaluate efficacy and safety of total glucosides of paeony in the treatment of 5
types of inflammatory arthritis Methods Databases such as Pubmed, Cochran Library …

C-reactive protein: pathophysiology, diagnosis, false test results and a novel diagnostic algorithm for clinicians

DS Mouliou - Diseases, 2023 - mdpi.com
The current literature provides a body of evidence on C-Reactive Protein (CRP) and its
potential role in inflammation. However, most pieces of evidence are sparse and …

Neuroimmune crosstalk in rheumatoid arthritis

D Gao, X Gao, F Yang, Q Wang - International journal of molecular …, 2022 - mdpi.com
Recent studies have demonstrated that immunological disease progression is closely
related to abnormal function of the central nervous system (CNS). Rheumatoid arthritis (RA) …

MACE and VTE across upadacitinib clinical trial programmes in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis

C Charles-Schoeman, E Choy, IB McInnes, E Mysler… - RMD open, 2023 - rmdopen.bmj.com
Objectives To provide an integrated analysis of major adverse cardiovascular events
(MACEs) and events of venous thromboembolism (VTE) and associated risk factors across …