De novo glioblastomas develop in older patients without prior clinical history of less
malignant tumors. Progressive glioblastomas are common among younger patients and …

Oncolytic virotherapy is the use of genetically engineered viruses that specifically target and
destroy tumor cells via their cytolytic replication cycle. Viral-mediated tumor destruction is …

Medulloblastomas are among the most common malignancies in childhood, and they are
associated with substantial mortality and morbidity. The molecular pathogenesis as well as …

Purpose: Advances in brain tumor biology indicate that transfer of p53 is an alternative
therapy for human gliomas. Consequently, we undertook a phase I clinical trial of p53 gene …

We have previously reported on the amplification and overexpression of the MDM2 proto-
oncogene in a subset of malignant gliomas without TP53 mutation (G. Reifenberger et al …

Meet the increasing need for effective brain tumor management with the highly anticipated
revision of Brain Tumors by Drs. Andrew H. Kaye and Edward R. Laws. Over the past …

Infiltrative astrocytic neoplasms are by far the most common malignant brain tumors in
adults. Clinically, they are highly problematic due to their widely invasive nature which …

More than thirty years elapsed since a protein, not yet called p53 at the time, was detected to
bind SV40 during viral infection. Thousands of papers later, p53 evolved as the main tumor …

Somatic mutations during stem cell division are responsible for several cancers. In principle,
a similar process could occur during the intense cell proliferation accompanying human …

Malignant gliomas have invasive properties that make them nearly impossible to cure
surgically. Most physicians agree that the best hope for long-term control lies with adjunctive …