ABSTRACT Author of Master Thesis: Dovile Kavaliauskaite Full title of Master Thesis:
Histological and immunohistochemical investigation of sodium valproate influence on …

Irinotecan(CPT-11), 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin, is a
semisynthetic analog of a naturally occurring alkaloid, camptothecin (CPT)(Fig. 1). It acts by …

TP53's role as guardian ofthe genome diminishes with age, as the probability of mutation
increases. Previous studies have shown an association between TP53 mutation and cancer …

Primary brain tumours and metastasis in the brain are both uncontrolled diseases leading to
death, no matter which aggressive surgical and adjuvant treatment is undertaken. High …

Astrocytomas are classified into four WHO1 grades, with the most malignant grade 4 or
glioblastoma multiforme (GBM) being the most lethal, with a mean survival of< 16 months …

Primary tumors of the central nervous system (CNS) account for approximately 2–3% of all
cancers. In Western countries, the annual incidence is approximately 15 patients per …

The goal of this research was to develop a p53 functional assay using p53 from the U373
human glioblastoma cell line. p53 is a tumor suppressor gene/protein that when inactivated …

Tumors of the central nervous system (CNS) can be categorized as primary or secondary.
Metastatic or secondary tumors of the CNS are increasing in frequency, as we are better …

In der vorliegenden Arbeit wurden der klinische Verlauf der Tumorerkrankung von 40
Kindern, die an einem Ependymom erkrankten, erfasst und 58 Tumorproben mittels …