The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also
by other pathways causing hyperpolarization of the underlying smooth muscle cells. This …

Oxidative stress-associated endothelial dysfunction is a key pathogenic factor underlying the
microvascular complications of metabolic disease. NADPH oxidase (Nox) is a major source …

Unlike sodium, potassium is vasoactive; for example, when infused into the arterial supply of
a vascular bed, blood flow increases. The vasodilation results from hyperpolarization of the …

Our view of the endothelium was transformed around 30 years ago, from one of an inert
barrier to that of a key endocrine organ central to cardiovascular function. This dramatic …

The endothelium maintains vascular homeostasis through the release of active vasodilators.
Although nitric oxide (NO) is recognized as the primary factor at level of conduit arteries …

The arterial endothelium critically contributes to blood pressure control by releasing
vasodilating autacoids such as nitric oxide, prostacyclin and a third factor or pathway termed …

Endothelial function refers to a multitude of physiological processes that maintain healthy
homeostasis of the vascular wall. Exposure of the endothelium to cardiac risk factors results …

Endothelium‐dependent relaxations are attributed to the release of various factors, such as
nitric oxide, carbon monoxide, reactive oxygen species, adenosine, peptides and …

There is now strong evidence that an endothelial mechanism, other than nitric oxide or
prostacyclin, exists for dilating arteries and arterioles. This third pathway has been named …