Polyguluronic acid alleviates doxorubicin-induced cardiotoxicity by suppressing Peli1-NLRP3 inflammasome-mediated pyroptosis

E Zhang, C Shang, M Ma, X Zhang, Y Liu, S Song… - Carbohydrate …, 2023 - Elsevier
Polyguluronic acid (PG), a polysaccharide from alginate, possesses excellent bioactivities.
We prepared high-purity PG with 10.41 kDa molecular weight (Mw) and a 59 average …

Fractionated whole body γ-irradiation aggravates arthritic severity via boosting NLRP3 and RANKL expression in adjuvant-induced arthritis model: the mitigative …

NM Thabet, MK Abdel-Rafei, MM Amin - Inflammopharmacology, 2023 - Springer
Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease associated with
oxidative stress that causes excruciating pain, discomfort, and joint destruction. Ebselen …

Recent developments in anti-inflammatory therapy

P Prasher, F Zacconi, K Dua, M Rathbone, J Withey - 2023 - books.google.com
Advances in Anti-inflammatory Therapy explores the cutting-edge in anti-inflammation
therapy in clear and concise language, with insights from academia and industry. Sections …

Concerted regulation of OPG/RANKL/NF‑κB/MMP-13 trajectories contribute to ameliorative capability of prodigiosin and/or low dose γ-radiation against adjuvant …

MK Abdel-Rafei, NM Thabet, MM Amin - International …, 2022 - Elsevier
Background Prodigiosin (PDG) is a microbial red dye with antioxidant and anti-inflammatory
properties, although its effect on rheumatoid arthritis (RA) remains uncertain. Also, multiple …

Total Saponins from Nigella glandulifera Seeds Ameliorate Adjuvant‐Induced Rheumatoid Arthritis in Rats by Inhibition of an Inflammatory Response and Bone …

L Zeng, C Li, H Jiang, Y Chen, Z Li… - BioMed Research …, 2021 - Wiley Online Library
Rheumatoid arthritis (RA) is a widespread inflammatory disease whose clinical
manifestations are joint swelling, pain, and disability, affecting approximately 1% of …

Evaluation of G2013 (α‐L‐guluronic acid) efficacy on PC‐3 cells through inhibiting the expression of inflammatory factors

Z Bagherian, A Mirshafiey… - Clinical and …, 2022 - Wiley Online Library
Given multiple treatment strategies for prostate cancer, its mortality rate is still high;
therefore, novel treatment strategies seem necessary. G2013 or α‐L‐guluronic acid is a new …

Clinical trials and future perspectives of antiinflammatory agents

A Kumar, PA Chawla, B Kapoor - Recent Developments in Anti …, 2023 - Elsevier
Antiinflammatory drugs are used widely to reduce inflammation that is involved in various
diseases such as Alzheimer, Parkinson, rheumatoid arthritis, asthma, infectious diseases …

The Efficacy of Two Specific Toll-Like Receptor 4 Antagonists (G2013 & M2000) In Clinical Inflammatory Disease

M Taeb, M Rahmani, L Sharifi… - Applied Sciences …, 2023 - hspublishing.org
Toll-like receptors (TLRs) are receptors of the innate immune system that detect pathogen-
associated molecular patterns and endogenous “danger” molecules. Among the family, the …