[HTML][HTML] Molecular mechanisms of schizophrenia: Insights from human genetics
Schizophrenia is a debilitating psychiatric disorder that affects millions of people worldwide;
however, its etiology is poorly understood at the molecular and neurobiological levels. A …
however, its etiology is poorly understood at the molecular and neurobiological levels. A …
Emerging roles of N-linked glycosylation in brain physiology and disorders
LR Conroy, TR Hawkinson, LEA Young… - Trends in Endocrinology …, 2021 - cell.com
N-linked glycosylation is a complex, co-and post-translational series of events that connects
metabolism to signaling in almost all cells. Metabolic assembly of N-linked glycans spans …
metabolism to signaling in almost all cells. Metabolic assembly of N-linked glycans spans …
Levetiracetam mechanisms of action: from molecules to systems
IJ Contreras-García, N Cárdenas-Rodríguez… - Pharmaceuticals, 2022 - mdpi.com
Epilepsy is a chronic disease that affects millions of people worldwide. Antiepileptic drugs
(AEDs) are used to control seizures. Even though parts of their mechanisms of action are …
(AEDs) are used to control seizures. Even though parts of their mechanisms of action are …
Acute social isolation and regrouping cause short-and long-term molecular changes in the rat medial amygdala
D Lavenda-Grosberg, M Lalzar, N Leser… - Molecular …, 2022 - nature.com
Social isolation poses a severe mental and physiological burden on humans. Most animal
models that investigate this effect are based on prolonged isolation, which does not mimic …
models that investigate this effect are based on prolonged isolation, which does not mimic …
Emerging roles of the human solute carrier 22 family
SW Yee, KM Giacomini - Drug Metabolism and Disposition, 2022 - ASPET
The human solute carrier 22 family (SLC22), also termed the organic ion transporter family,
consists of 28 distinct multi-membrane spanning proteins, which phylogenetically cluster …
consists of 28 distinct multi-membrane spanning proteins, which phylogenetically cluster …
Acetylcholinesterase inhibitors for the treatment of Alzheimer's disease–a patent review (2016–present)
M Bortolami, D Rocco, A Messore… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction–AD, the most common form of dementia, has a multifactorial etiology, and the
current therapy (AChEIs and memantine) is unable to interrupt its progress and fatal …
current therapy (AChEIs and memantine) is unable to interrupt its progress and fatal …
Development of SV2A ligands for epilepsy treatment: a review of levetiracetam, brivaracetam, and padsevonil
PP Wu, BR Cao, FY Tian, ZB Gao - Neuroscience Bulletin, 2024 - Springer
Epilepsy is a common neurological disorder that is primarily treated with antiseizure
medications (ASMs). Although dozens of ASMs are available in the clinic, approximately …
medications (ASMs). Although dozens of ASMs are available in the clinic, approximately …
Nicotine‐Mediated Rescue of α‐Synuclein Toxicity Requires Synaptic Vesicle Glycoprotein 2 in Drosophila
AL Olsen, SG Clemens, MB Feany - Movement Disorders, 2023 - Wiley Online Library
Background Parkinson's disease (PD) is characterized by α‐synuclein aggregation and loss
of dopamine neurons. Risk of PD arises due to a combination of genetic and environmental …
of dopamine neurons. Risk of PD arises due to a combination of genetic and environmental …
Reconstruction of vesicle assemblies with DNA nanorulers for resolving heterogeneity of vesicles in live cells
Nanoscale vesicles such as synaptic vesicles play a pivotal role in efficient interneuronal
communications in vivo. However, the coexistence of single vesicle and vesicle clusters in …
communications in vivo. However, the coexistence of single vesicle and vesicle clusters in …
Adaptive Changes in Detoxification Metabolism and Transmembrane Transport of Bombyx mori Malpighian Tubules to Artificial Diet
L Liu, D Zhao, G Wang, Q He, Y Song, Y Jiang… - International Journal of …, 2023 - mdpi.com
The high adaptability of insects to food sources has contributed to their ranking among the
most abundant and diverse species on Earth. However, the molecular mechanisms …
most abundant and diverse species on Earth. However, the molecular mechanisms …