Superoxide anion chemistry—Its role at the core of the innate immunity

CMC Andrés, JM Pérez de la Lastra… - International journal of …, 2023 - mdpi.com
Classically, superoxide anion O2•− and reactive oxygen species ROS play a dual role. At
the physiological balance level, they are a by-product of O2 reduction, necessary for cell …

New horizons of macrophage immunomodulation in the healing of diabetic foot ulcers

CW Lin, CM Hung, WJ Chen, JC Chen, WY Huang… - Pharmaceutics, 2022 - mdpi.com
Diabetic foot ulcers (DFUs) are one of the most costly and troublesome complications of
diabetes mellitus. The wound chronicity of DFUs remains the main challenge in the current …

Oral metal‐free melanin nanozymes for natural and durable targeted treatment of inflammatory bowel disease (IBD)

Q Huang, Y Yang, Y Zhu, Q Chen, T Zhao, Z Xiao… - Small, 2023 - Wiley Online Library
Oral antioxidant nanozymes bring great promise for inflammatory bowel disease (IBD)
treatment. To efficiently eliminate reactive oxygen species (ROS), various metal‐based …

[HTML][HTML] Sepsis-mediated renal dysfunction: pathophysiology, biomarkers and role of phytoconstituents in its management

A Balkrishna, S Sinha, A Kumar, V Arya… - Biomedicine & …, 2023 - Elsevier
Sepsis has evolved as an enormous health issue amongst critically ill patients. It is a major
risk factor that results in multiple organ failure and shock. Acute kidney injury (AKI) is one of …

[HTML][HTML] Forsythiaside A alleviates acute lung injury by inhibiting inflammation and epithelial barrier damages in lung and colon through PPAR-γ/RXR-α complex

J Wang, X Xue, X Zhao, L Luo, J Liu, S Dai… - Journal of Advanced …, 2024 - Elsevier
Introduction Acute lung injury (ALI) is a lung disease characterized by inflammation and still
requires further drug development. Forsythiaside A as the active compound of Forsythiae …

[HTML][HTML] Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment

MG Monaghan, R Borah, C Thomsen… - Advanced Drug Delivery …, 2023 - Elsevier
Diabetic foot ulcers (DFUs) are a devastating complication for diabetic patients that have
debilitating effects and can ultimately lead to limb amputation. Healthy wounds progress …

Macrophage polarization in inflammatory bowel disease

K Zhang, J Guo, W Yan, L Xu - Cell Communication and Signaling, 2023 - Springer
The growing prevalence of inflammatory bowel disease (IBD) has encouraged research
efforts, which have contributed to gradual improvements in our understanding of IBD …

Irisin drives macrophage anti-inflammatory differentiation via JAK2-STAT6-dependent activation of PPARγ and Nrf2 signaling

Y Tu, J Liu, D Kong, X Guo, J Li, Z Long, J Peng… - Free Radical Biology …, 2023 - Elsevier
Irisin is an exercise-induced myokine that alleviates inflammation and obesity. The induction
of anti-inflammatory (M2) macrophage is facilitated for treatment of sepsis and associated …

[HTML][HTML] Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications

B Kalyanaraman, G Cheng, M Hardy - Redox Biology, 2024 - Elsevier
In this review, we explore how short-chain fatty acids (SCFAs) produced by the gut
microbiome affect Parkinson's disease (PD) through their modulatory interactions with alpha …

Macrophage/microglia polarization for the treatment of diabetic retinopathy

Y Yao, J Li, Y Zhou, S Wang, Z Zhang… - Frontiers in …, 2023 - frontiersin.org
Macrophages/microglia are immune system defense and homeostatic cells that develop
from bone marrow progenitor cells. According to the different phenotypes and immune …