Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer
A variety of targeted anticancer agents have been successfully introduced into clinical
practice, largely reflecting their ability to inhibit specific molecular alterations that are …
practice, largely reflecting their ability to inhibit specific molecular alterations that are …
The evolving role of radiotherapy in non-small cell lung cancer
Lung cancer is the most commonly diagnosed cancer and biggest cause of cancer mortality
worldwide with non-small cell lung cancer (NSCLC) accounting for most cases …
worldwide with non-small cell lung cancer (NSCLC) accounting for most cases …
[HTML][HTML] Alternative multidisciplinary management options for locally advanced NSCLC during the coronavirus disease 2019 global pandemic
S Kumar, S Chmura, C Robinson, SH Lin… - Journal of Thoracic …, 2020 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic is currently accelerating.
Patients with locally advanced NSCLC (LA-NSCLC) may require treatment in locations …
Patients with locally advanced NSCLC (LA-NSCLC) may require treatment in locations …
A reinforcement learning approach for finding optimal policy of adaptive radiation therapy considering uncertain tumor biological response
S Ebrahimi, GJ Lim - Artificial Intelligence in Medicine, 2021 - Elsevier
Recent studies have shown that a tumor's biological response to radiation varies over time
and has a dynamic nature. Dynamic biological features of tumor cells underscore the …
and has a dynamic nature. Dynamic biological features of tumor cells underscore the …
[HTML][HTML] Same-day consultation, simulation and lung Stereotactic Ablative Radiotherapy delivery on a Magnetic Resonance-linac
MA Palacios, S Verheijen, FL Schneiders… - Physics and Imaging in …, 2022 - Elsevier
Abstract Background and Purpose Magnetic resonance-guided radiotherapy (MRgRT) with
real-time intra-fraction tumor motion monitoring allows for high precision Stereotactic …
real-time intra-fraction tumor motion monitoring allows for high precision Stereotactic …
Targeting therapy-resistant lung cancer stem cells via disruption of the AKT/TSPYL5/PTEN positive-feedback loop
IG Kim, JH Lee, SY Kim, CK Heo, RK Kim… - Communications …, 2021 - nature.com
Cancer stem cells (CSCs) are regarded as essential targets to overcome tumor progression
and therapeutic resistance; however, practical targeting approaches are limited. Here, we …
and therapeutic resistance; however, practical targeting approaches are limited. Here, we …
Optimized hypofractionation can markedly improve tumor control and decrease late effects for head and neck cancer
I Shuryak, EJ Hall, DJ Brenner - International Journal of Radiation …, 2019 - Elsevier
Purpose Treatment of fast-growing, human papillomavirus–negative, head and neck
cancers (HNCs) remains challenging from the perspectives of both tumor control and late …
cancers (HNCs) remains challenging from the perspectives of both tumor control and late …
Isoflavone-mediated radioprotection involves regulation of early endothelial cell death and inflammatory signaling in Radiation-Induced lung injury
MD Fountain, LA McLellan, NL Smith… - … journal of radiation …, 2020 - Taylor & Francis
Purpose: Vascular damage and inflammation are limiting toxic effects of lung cancer
radiotherapy, which lead to pneumonitis and pulmonary fibrosis. We have demonstrated that …
radiotherapy, which lead to pneumonitis and pulmonary fibrosis. We have demonstrated that …
Hypofractionated Radiotherapy followed by Hypofractionated Boost with weekly concurrent chemotherapy for Unresectable Stage III Non–Small Cell Lung Cancer …
R Zhou, B Qiu, M Xiong, YM Liu, KQ Peng… - International Journal of …, 2023 - Elsevier
Purpose We launched a prospective phase 2 clinical trial to explore the safety and efficacy
of hypofractionated radiation therapy (hypo-RT) followed by hypofractionated boost (hypo …
of hypofractionated radiation therapy (hypo-RT) followed by hypofractionated boost (hypo …
[HTML][HTML] Image guidance: past and future of radiotherapy
H Herrmann, Y Seppenwoolde, D Georg… - Der Radiologe, 2019 - ncbi.nlm.nih.gov
Image guidance has been playing a decisive role throughout the history of radiotherapy, but
developments in 3D-and 4D imaging data acquisition using computed tomography (CT) …
developments in 3D-and 4D imaging data acquisition using computed tomography (CT) …