Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …

Organoids are in vitro self-assembling, organ-like, three-dimensional cellular structures that
stably retain key characteristics of the respective organs. Organoids can be generated from …

Gastric cancer heterogeneity represents a barrier to disease management. We generated a
comprehensive single-cell atlas of gastric cancer (> 200,000 cells) comprising 48 samples …

Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …

Organoids are self-organizing, expanding 3D cultures derived from stem cells. Using tissue
derived from patients, these miniaturized models recapitulate various aspects of patient …

Organoids are established through in vitro 3D culture, and they can mimic the structure and
physiological functions of organs or tissues in vivo. Organoids have attracted much attention …

We are entering an era of medicine where increasingly sophisticated data will be obtained
from patients to determine proper diagnosis, predict outcomes and direct therapies. We …

Aldehyde dehydrogenases (ALDHs) are promising cancer drug targets, as certain isoforms
are required for the survival of stem-like tumor cells. We have discovered selective inhibitors …

Malignant tumors are one of the leading causes of death which impose an increasingly
heavy burden on all countries. Therefore, the establishment of research models that closely …

The earliest events during human tumour initiation, although poorly characterized, may hold
clues to malignancy detection and prevention. Here we model occult preneoplasia by …