Currently, obesity has become a global health issue and is referred to as an epidemic.
Dysfunctional obese adipose tissue plays a pivotal role in the development of insulin …

Diabetes is a chronic metabolic disorder characterized by inappropriately elevated glucose
levels as a result of impaired pancreatic β cell function and insulin resistance. Extensive …

Lipid droplets are cytoplasmic organelles that store neutral lipids and are critically important
for energy metabolism. Their function in energy storage is firmly established and …

Pancreatic β cell neogenesis and proliferation during the neonatal period are critical for the
generation of sufficient pancreatic β cell mass/reserve and have a profound impact on long …

The contact sites that the endoplasmic reticulum (ER) forms with mitochondria, called
mitochondria-associated membranes (MAMs), are a hot topic in biological research, and …

A primary cause of disease progression in type 2 diabetes (T2D) is β cell dysfunction due to
inflammatory stress and insulin resistance. However, preventing β cell exhaustion under …

Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …

Acrolein is a typical food and environmental pollutant and a risk factor for diabetes. The
primary pathogenesis of diabetes is insulin deficiency and resistance. Ferroptosis is an iron …

Proinsulin is a misfolding-prone protein, making its biosynthesis in the endoplasmic
reticulum (ER) a stressful event. Pancreatic β-cells overcome ER stress by activating the …

Endocrine disrupting chemicals (EDCs), a heterogeneous group of exogenous chemicals
that can interfere with any aspect of endogenous hormones, represent an emerging global …