The circadian rhythm plays a fundamental role in regulating biological functions, including
sleep–wake preference, body temperature, hormonal secretion, food intake, and cognitive …

Circadian rhythms occur in almost all species and control vital aspects of our physiology,
from sleeping and waking to neurotransmitter secretion and cellular metabolism …

Circadian rhythms and cellular metabolism are intimately linked. Here, we reveal that a high-
fat diet (HFD) generates a profound reorganization of specific metabolic pathways, leading …

Mammalian circadian rhythms are controlled by endogenous biological oscillators, including
a master clock located in the hypothalamic suprachiasmatic nuclei (SCN). Since the period …

Circadian (∼ 24 hour) clocks are fundamentally important for coordinated physiology in
organisms as diverse as cyanobacteria and humans. All current models of the molecular …

Ageing leads to a functional deterioration of many brain systems, including the circadian
clock—an internal time-keeping system that generates∼ 24-hour rhythms in physiology and …

Many immune parameters show systematic fluctuations over the 24‐h day in human blood.
Circulating naive T‐cells and production of proinflammatory cytokines, like interleukin‐12 (IL …

There currently exists a modern epidemic of sleep loss, triggered by the changing demands
of our 21st century lifestyle that embrace 'round-the-clock'remote working hours, access to …

Abstract Melatonin (N-acetyl-5-methoxytryptamine) has revealed itself as an ubiquitously
distributed and functionally diverse molecule. The mechanisms that control its synthesis …

Objective: Previous cross‐sectional studies have observed alterations in activity rhythms in
dementia patients but the direction of causation is unclear. We determined whether …