Anthracyclines are highly effective chemotherapeutic agents, used for a wide variety of
malignancies. Cardiotoxicity is a well‑recognized side effect of anthracycline therapy that …

Simple Summary Breast cancer (BC) is the most common cancer diagnosed among women
worldwide. Despite numerous studies, the pathogenesis of BC is still poorly understood, and …

In breast cancer (BC) epithelial cells, the mitogenic action of estradiol is transduced through
binding to two receptors, ERα and ERβ, which act as transcription factors. Anti-estrogens …

Breast cancer exhibits various epigenetic abnormalities that regulate gene expression and
contribute to tumor characteristics. Epigenetic alterations play a significant role in cancer …

Breast cancer remains a common cause of cancer-related death in women. Therefore,
further studies are necessary for the comprehension of breast cancer and the revolution of …

The histone acetylation modifications (HAMs) influence a large number of cellular functions.
They are mediated through histone acetyltransferase (HAT) and histone deacetylase …

Epigenetic modifications can affect the long‐term gene expression without any change in
nucleotide sequence of the DNA. Epigenetic processes intervene in the cell differentiation …

Transcriptional regulation of ESR1, the gene that encodes for estrogen receptor α (ER), is
critical for regulating the downstream effects of the estrogen signaling pathway in breast …

Cancer is a main public health problem all over the world. It affects millions of humans no
matter their age, gender, education, or social status. Although chemotherapy is the main …

Estrogen receptor α (ERα) is a ligand‐dependent transcription factor that regulates the
expression of estrogen‐responsive genes. Approximately 70% of patients with breast cancer …