Neuropeptide system regulation of prefrontal cortex circuitry: implications for neuropsychiatric disorders

SM Casello, RJ Flores, HE Yarur, H Wang… - Frontiers in Neural …, 2022 - frontiersin.org
Neuropeptides, a diverse class of signaling molecules in the nervous system, modulate
various biological effects including membrane excitability, synaptic transmission and …

Development, diversity, and death of MGE-derived cortical interneurons

RH Williams, T Riedemann - International Journal of Molecular Sciences, 2021 - mdpi.com
In the mammalian brain, cortical interneurons (INs) are a highly diverse group of cells. A key
neurophysiological question concerns how each class of INs contributes to cortical circuit …

Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

E Lee, S Lee, JJ Shin, W Choi, C Chung, S Lee… - Nature …, 2021 - nature.com
Abstract NMDA receptor (NMDAR) and GABA neuronal dysfunctions are observed in animal
models of autism spectrum disorders, but how these dysfunctions impair social cognition …

The maternal brain is more flexible and responsive at rest: effective connectivity of the parental caregiving network in postpartum mothers

ER Orchard, K Voigt, S Chopra, T Thapa, PGD Ward… - Scientific reports, 2023 - nature.com
The field of neuroscience has largely overlooked the impact of motherhood on brain function
outside the context of responses to infant stimuli. Here, we apply spectral dynamic causal …

CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolation stress-induced social impairments in male mice

B Guo, K Xi, H Mao, K Ren, H Xiao, ND Hartley… - Neuron, 2024 - cell.com
Social isolation is a risk factor for multiple mood disorders. Specifically, social isolation can
remodel the brain, causing behavioral abnormalities, including sociability impairments …

Neurochemical alterations in social anxiety disorder (SAD): a systematic review of proton magnetic resonance spectroscopic studies

S Elsaid, DS Rubin-Kahana, S Kloiber… - International Journal of …, 2022 - mdpi.com
(1) Objective: Considering that current knowledge of mechanisms involved in the molecular
pathogenesis of Social Anxiety Disorder (SAD) is limited, we conducted a systematic review …

Neuropeptide Y reduces social fear in male mice: Involvement of Y1 and Y2 Receptors in the dorsolateral septum and central amygdala

J Kornhuber, I Zoicas - International journal of molecular sciences, 2021 - mdpi.com
Neuropeptide Y (NPY) has anxiolytic-like effects and facilitates the extinction of cued and
contextual fear in rodents. We previously showed that intracerebroventricular administration …

Differences in mGluR5 Availability Depending on the Level of Social Avoidance in Drug-Naïve Young Patients with Major Depressive Disorder

JH Kim, YH Joo, YD Son, HK Kim… - … Disease and Treatment, 2022 - Taylor & Francis
Background Previous research has shown that metabotropic glutamate receptor-5 (mGluR5)
signaling is significantly involved in social avoidance. We investigated the relationship …

Neural circuits underlying social fear in rodents: An integrative computational model

V Alfieri, A Mattera, G Baldassarre - Frontiers in systems neuroscience, 2022 - frontiersin.org
Social avoidance in rodents arises from a complex interplay between the prefrontal cortex
and subcortical structures, such as the ventromedial hypothalamus and the dorsal …

The maternal brain is more flexible and responsive at rest: effective connectivity of the parental caregiving network in postpartum mothers

ER Orchard, K Voigt, S Chopra, T Thapa, PGD Ward… - bioRxiv, 2022 - biorxiv.org
The field of neuroscience has largely overlooked the impact of motherhood on brain function
outside the context of responses to infant stimuli. Here, we apply spectral dynamic causal …