Structural and functional integrity of the cerebral vasculature ensures proper brain
development and function, as well as healthy aging. The inability of the brain to store energy …

Multidimensional progressive declines in the absence of standard biomarkers for
neurodegeneration are observed commonly in the development of schizophrenia, and are …

Drug repositioning is a promising drug development technique to identify new indications for
existing drugs. However, existing computational models only make use of lower-order …

Previous studies have observed a significant comorbidity between Alzheimer's disease (AD)
and some other neuropsychiatric disorders. However, the mechanistic connections between …

Background Schizophrenia spectrum disorders (SSD) can be associated with
neurodegenerative processes causing disruption of neuronal, synaptic, or axonal integrity …

Recent evidence supports accelerated cognitive decline and brain changes in middle-aged
and older people with schizophrenia, relative to the general population. More research in …

We hypothesized that cerebral white matter deficits in schizophrenia (SZ) are driven in part
by accelerated white matter aging and are associated with cognitive deficits. We used a …

Abstract Brodmann Area 46 (BA46) has long been regarded as a hotspot of disease
pathology in individuals with schizophrenia (SCH) and major depressive disorder (MDD) …

Background Thalamocortical white matter connectivity is disrupted in psychosis and is
hypothesized to play a role in its etiology and associated cognitive impairment. Attenuated …

Neuroimaging research has uncovered a multitude of neural abnormalities associated with
psychopathology, but few prediction-based studies have been conducted during …