The oxytocin receptor: from intracellular signaling to behavior

B Jurek, ID Neumann - Physiological reviews, 2018 - journals.physiology.org
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

[PDF][PDF] Activity-regulated transcription: bridging the gap between neural activity and behavior

EL Yap, ME Greenberg - Neuron, 2018 - cell.com
Gene transcription is the process by which the genetic codes of organisms are read and
interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As …

Prefrontal cortex development in health and disease: lessons from rodents and humans

M Chini, IL Hanganu-Opatz - Trends in neurosciences, 2021 - cell.com
The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in
modern neuroscience. The PFC has a Janus-faced nature: it enables sophisticated cognitive …

[PDF][PDF] Calcium channels, synaptic plasticity, and neuropsychiatric disease

E Nanou, WA Catterall - Neuron, 2018 - cell.com
Voltage-gated calcium channels couple depolarization of the cell-surface membrane to entry
of calcium, which triggers secretion, contraction, neurotransmission, gene expression, and …

[HTML][HTML] Dendritic spine plasticity: function and mechanisms

K Runge, C Cardoso, A De Chevigny - Frontiers in synaptic …, 2020 - frontiersin.org
Dendritic spines are small protrusions studding neuronal dendrites, first described in 1888
by Ramón y Cajal using his famous Golgi stainings. Around 50 years later the advance of …

[PDF][PDF] Different neuronal activity patterns induce different gene expression programs

KM Tyssowski, NR DeStefino, JH Cho, CJ Dunn… - Neuron, 2018 - cell.com
A vast number of different neuronal activity patterns could each induce a different set of
activity-regulated genes. Mapping this coupling between activity pattern and gene induction …

[PDF][PDF] Memory engram cells have come of age

S Tonegawa, X Liu, S Ramirez, R Redondo - Neuron, 2015 - cell.com
The idea that memory is stored in the brain as physical alterations goes back at least as far
as Plato, but further conceptualization of this idea had to wait until the 20 th century when …

Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression

JA Beagan, ED Pastuzyn, LR Fernandez, MH Guo… - Nature …, 2020 - nature.com
Neuronal activation induces rapid transcription of immediate early genes (IEGs) and longer-
term chromatin remodeling around secondary response genes (SRGs). Here, we use high …

The widespread regulation of microRNA biogenesis, function and decay

J Krol, I Loedige, W Filipowicz - Nature reviews genetics, 2010 - nature.com
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression
that are∼ 21 nucleotides in length and control many developmental and cellular processes …

On-demand cell-autonomous gene therapy for brain circuit disorders

Y Qiu, N O'Neill, B Maffei, C Zourray… - Science, 2022 - science.org
Several neurodevelopmental and neuropsychiatric disorders are characterized by
intermittent episodes of pathological activity. Although genetic therapies offer the ability to …