We used genome-wide sequencing methods to study stimulus-dependent enhancer function
in mouse cortical neurons. We identified∼ 12,000 neuronal activity-regulated enhancers …

The proper construction of neural circuits requires the generation of diverse cell types, their
distribution to defined regions, and their specific and appropriate wiring. A major objective in …

Voltage-gated calcium (Ca2+) channels are key transducers of membrane potential
changes into intracellular Ca2+ transients that initiate many physiological events. There are …

Neuronal activity induces the post-translational modification of synaptic molecules, promotes
localized protein synthesis within dendrites and activates gene transcription, thereby …

Memories are believed to be encoded by sparse ensembles of neurons in the brain.
However, it remains unclear whether there is functional heterogeneity within individual …

Homeostatic mechanisms stabilize neural circuit function by keeping firing rates within a set-
point range, but whether this process is gated by brain state is unknown. Here, we monitored …

The NAD-dependent deacetylase Sir2 was initially identified as a mediator of replicative
lifespan in budding yeast and was subsequently shown to modulate longevity in worms and …

The nervous system adapts to experience by inducing a transcriptional program that controls
important aspects of synaptic plasticity. Although the molecular mechanisms of experience …

Adverse early life events can induce long-lasting changes in physiology and behavior. We
found that early-life stress (ELS) in mice caused enduring hypersecretion of corticosterone …

Recent studies have provided long-sought evidence that behavioural learning involves
specific synapse gain and elimination processes, which lead to memory traces that influence …