Stressful events during adulthood are potent adverse environmental factors that can
predispose individuals to psychiatric disorders, including depression; however, many …

The c-fos gene (also known as Fos) is induced by a broad range of stimuli and is a reliable
marker for neural activity. Here we demonstrate that multiple enhancers surrounding the c …

The mammalian brain is composed of thousands of interacting neural cell types. Systematic
approaches to establish the molecular identity of functional populations of neurons would …

Learning and memory are associated with the formation and modification of neuronal
assemblies: populations of neurons that encode what has been learned and mediate …

Proprioceptive neurons (PNs) are essential for the proper execution of all our movements by
providing muscle sensory feedback to the central motor network. Here, using deep single …

In the nervous system, many intracellular responses to elevated calcium are mediated by
CaM kinases (CaMKs), a family of protein kinases whose activities are initially modulated by …

Activity-dependent gene expression triggered by Ca 2+ entry into neurons is critical for
learning and memory, but whether specific sources of Ca 2+ act distinctly or merely supply …

Massively parallel single-cell RNA sequencing can precisely resolve cellular diversity in a
high-throughput manner at low cost, but unbiased isolation of intact single cells from …

Although many transcription factors are known to control important aspects of neural
development, the genome-wide programs that are directly regulated by these factors are not …

Immediate-early genes (IEGs) are rapidly activated after sensory and behavioral experience
and are believed to be crucial for converting experience into long-term memory. Neuronal …