Genetic labeling of neurons with a specific response feature is an emerging technology for
precise dissection of brain circuits that are functionally heterogeneous at the single-cell …

One of the exceptional properties of the brain is its ability to acquire new knowledge through
learning and to store that information through memory. The epigenetic mechanisms linking …

Brain networks can support learning by promoting acquisition of task-relevant information or
by adhering to validated rules, but the mechanisms involved are poorly understood. Upon …

Mutations in MECP2 cause Rett syndrome (RTT), an X-linked neurological disorder
characterized by regressive loss of neurodevelopmental milestones and acquired …

The activity of neuronal circuits of the neocortex underlies our ability to perceive the world
and interact with our environment. During development, these circuits emerge from dynamic …

Background Considerable clinical heterogeneity has been well documented amongst
individuals with autism spectrum disorders (ASD). However, little is known about the …

Neuronal networks are the standard heuristic model today for describing brain activity
associated with animal behavior. Recent studies have revealed an extensive role for a …

Alzheimer's disease (AD) is the most common cause of dementia in older adults.
Neuropathological and imaging studies have demonstrated a progressive and stereotyped …

The assembly of specific synaptic connections during development of the nervous system
represents a remarkable example of cellular recognition and differentiation. Neurons employ …

In the adult hippocampus, synaptic plasticity is important for information processing,
learning, and memory encoding. Astrocytes, the most common glial cells, play a pivotal role …