Sarcopenic obesity, or the loss of muscle mass and function associated with excess
adiposity, is a largely untreatable medical condition associated with diminished quality of life …

Several molecular mechanisms are involved in the regulation of skeletal muscle function.
Among them, mitochondrial activity can be identified. The mitochondria is an important and …

The purpose of this study is to determine whether moderate aerobic exercise training
improves high‐fat diet‐induced alterations in mitochondrial function and structure in the …

Background and aims A diminution in skeletal muscle mitochondrial function due to ectopic
lipid accumulation and excess nutrient intake is thought to contribute to insulin resistance …

Aims/hypothesis Mitochondria operate in networks, adapting to external stresses and
changes in cellular metabolic demand and are subject to various quality control …

Excessive storage of lipid droplets (LDs) in skeletal muscles is a hallmark of type 2 diabetes.
However, LD morphology displays a high degree of subcellular heterogeneity and varies …

The continuous dynamic reshaping of mitochondria by fusion and fission events is critical to
keep mitochondrial quality and function under control in response to changes in energy and …

Insulin resistance is a critical pathophysiological process in the onset and advancement of
type 2 diabetes mellitus. It is well-recognized that alterations in the metabolism of lipids and …

Obesity-induced skeletal muscle (SKM) inflexibility is closely linked to mitochondrial
dysfunction. The present study aimed to evaluate the effects of melatonin on the red vastus …

There is a debate on whether lipid-mediated insulin resistance derives from an increased or
decreased capacity of muscle to oxidize fats. Here, we examine the involvement of muscle …