Aging conundrum: A perspective for ovarian aging

J Wu, Y Liu, Y Song, L Wang, J Ai, K Li - Frontiers in Endocrinology, 2022 - frontiersin.org
Progressive loss of physiological integrity and accumulation of degenerative changes
leading to functional impairment and increased susceptibility to diseases are the main …

Transzonal projections: Essential structures mediating intercellular communication in the mammalian ovarian follicle

HJ Clarke - Molecular Reproduction and Development, 2022 - Wiley Online Library
The development of germ cells relies on contact and communication with neighboring
somatic cells that provide metabolic support and regulatory signals. In females, contact is …

The stability of the anti-Müllerian hormone in serum and plasma samples under various preanalytical conditions

R Vrzáková, V Šimánek, O Topolčan, V Vurm, D Slouka… - Diagnostics, 2023 - mdpi.com
The anti-Müllerian hormone (AMH) is a glycoprotein that plays an important role in prenatal
sex differentiation. It is used as a biomarker in polycystic ovary syndrome (PCOS) …

Neuregulin 1 (NRG1) modulates oocyte nuclear maturation during IVM and improves post-IVF embryo development

TT Dellaqua, RA Vígaro, LCZ Janini, M Dal Canto… - Theriogenology, 2023 - Elsevier
Oocyte in vitro maturation (IVM) is still a major challenge in human and animal assisted
reproduction. Gradual instead of abrupt activation of the ovulatory cascade during IVM has …

Oocyte secreted factors control genes regulating FSH signaling and the maturation cascade in cumulus cells: the oocyte is not in a hurry

J Buratini, TT Dellaqua, PF de Lima… - Journal of Assisted …, 2023 - Springer
Purpose To assess the effects of the oocyte on mRNA abundance of FSHR, AMH and major
genes of the maturation cascade (AREG, EREG, ADAM17, EGFR, PTGS2, TNFAIP6, PTX3 …

Metabolic state of human blastocysts measured by fluorescence lifetime imaging microscopy

M Venturas, JS Shah, X Yang, TH Sanchez… - Human …, 2022 - academic.oup.com
STUDY QUESTION Can non-invasive metabolic imaging via fluorescence lifetime imaging
microscopy (FLIM) detect variations in metabolic profiles between discarded human …

The impact of microplastics on female reproduction and early life

J Yang, J Kamstra, J Legler, H Aardema - Animal Reproduction, 2023 - SciELO Brasil
Plastic pollution in our environment is one of the most important global health concerns right
now. Micro-and nanoplastics (MNPs) are taken up by both humans and animals, mainly via …

Evidence of FSH-ootoxicity from the mouse model: recognition of an important work and a note on the novelty of the hypothesis

J Buratini, M Dal Canto… - Molecular Human …, 2023 - academic.oup.com
Sir, We have read with great interest the recently published MHR article by Bernstein et
al.(2023):'Maternal age and gonadotrophin elevation cooperatively decrease viable …

Ovarian aging: mechanisms and intervention strategies

Z Zhu, W Xu, L Liu - Medical Review, 2023 - degruyter.com
Ovarian reserve is essential for fertility and influences healthy aging in women. Advanced
maternal age correlates with the progressive loss of both the quantity and quality of oocytes …

Chromatin Morphology in Human Germinal Vesicle Oocytes and Their Competence to Mature in Stimulated Cycles

D Salimov, T Lisovskaya, J Otsuki, A Gzgzyan… - Cells, 2023 - mdpi.com
The search for simple morphological predictors of oocyte quality is an important task for
assisted reproduction technologies (ARTs). One such predictor may be the morphology of …