The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

With regard to the varied, nonculinary uses of hot pepper, there is apparently little new under
the sun. For example, Incas burned dried chili peppers to combat the invading Spaniards by …

Transient receptor potential vanilloid 1 (TRPV1) is an ion channel that is gated by noxious
heat, capsaicin and other diverse stimuli. It is a nonselective cation channel that prefers …

Some synthetic agonists of the VR1 vanilloid (capsaicin) receptor also inhibit the facilitated
transport into cells of the endogenous cannabinoid anandamide (arachidonoylethanolamide …

The pharmacological desensitization of receptors is a fundamental mechanism for
regulating the activity of neuronal systems. The TRPA1 channel plays a key role in the …

Vanilloid receptor-1 (TRPV1) is a non-selective cation channel, predominantly expressed by
peripheral sensory neurones, which is known to play a key role in the detection of noxious …

Fatty acids (FAs) are not only essential components of cellular energy storage and structure,
but play crucial roles in signalling. Here we present a toolkit of photoswitchable FA …

In the late 1990's, a series of experiments carried out independently in two laboratories led
to establish an important connection between the function of the endocannabinoids, which …

The transient receptor potential (TRP) A1 channel is involved in the transduction of
inflammation‐induced noxious stimuli from the periphery. Previous studies have …

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the
progress made in this area of signaling research has yielded findings that offer the potential …