L-arginine metabolism as pivotal interface of mutual host–microbe interactions in the gut

B Nüse, T Holland, M Rauh, RG Gerlach, J Mattner - Gut Microbes, 2023 - Taylor & Francis
ABSTRACT L-arginine (L-arg) is a versatile amino acid and a central intestinal metabolite in
mammalian and microbial organisms. Thus, L-arg participates as precursor of multiple …

The emerging role of oral microbiota in oral cancer initiation, progression and stemness

PJ Saikia, L Pathak, S Mitra, B Das - Frontiers in Immunology, 2023 - frontiersin.org
Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy among the Head
and Neck cancer. OSCCs are highly inflammatory, immune-suppressive, and aggressive …

Dysbiosis of skin microbiome and gut microbiome in melanoma progression

C Mekadim, HK Skalnikova, J Cizkova, V Cizkova… - BMC microbiology, 2022 - Springer
Background The microbiome alterations are associated with cancer growth and may
influence the immune system and response to therapy. Particularly, the gut microbiome has …

Protective effects of a new generation of probiotic Bacteroides fragilis against colitis in vivo and in vitro

Q He, M Niu, J Bi, N Du, S Liu, K Yang, H Li, J Yao… - Scientific Reports, 2023 - nature.com
Bacteroides fragilis, one of the potential next-generation probiotics, but its protective
mechanism is not yet known. We aimed to characterize the anti-inflammatory effect of B …

Colonocyte-derived lactate promotes E. coli fitness in the context of inflammation-associated gut microbiota dysbiosis

SJ Taylor, MG Winter, CC Gillis, LA Silva, AL Dobbins… - Microbiome, 2022 - Springer
Background Intestinal inflammation disrupts the microbiota composition leading to an
expansion of Enterobacteriaceae family members (dysbiosis). Associated with this shift in …

[HTML][HTML] A systemic review of the role of enterotoxic Bacteroides fragilis in colorectal cancer

N Scott, E Whittle, P Jeraldo, N Chia - Neoplasia, 2022 - Elsevier
Enterotoxigenic Bacteroides fragilis (ETBF) has received significant attention for a possible
association with, or causal role in, colorectal cancer (CRC). The goal of this review was to …

[HTML][HTML] Structure and assembly of type VI secretion system cargo delivery vehicle

W He, K Wu, Z Ouyang, Y Bai, W Luo, D Wu, H An… - Cell Reports, 2023 - cell.com
Type VI secretion system is widely used in Gram-negative bacteria for injecting toxic
effectors into neighboring prokaryotic or eukaryotic cells. Various effectors can be loaded …

The involvement of gut microbiota in the anti-tumor effect of carnosic acid via IL-17 suppression in colorectal cancer

S Li, H Yang, L Li, W Wang, HY Tan, Y Qu… - Chemico-biological …, 2022 - Elsevier
Colorectal cancer (CRC) is a malignant tumor that threatens human health worldwide.
Disturbance of the gut microbiota caused by various external factors is one of the leading …

The interplay of sex steroids, the immune response, and the intestinal microbiota

F Pace, PI Watnick - Trends in Microbiology, 2021 - cell.com
The role of sex steroids in mammalian maturation is well established. Recently, it has been
increasingly appreciated that sex steroids also play an important role in the propensity of …

[HTML][HTML] Fecal microbial biomarkers combined with multi-target stool DNA test improve diagnostic accuracy for colorectal cancer

JQ Fan, WF Zhao, QW Lu, FR Zha, LB Lv… - World Journal of …, 2023 - ncbi.nlm.nih.gov
BACKGROUND Colorectal cancer (CRC) is a major global health burden. The current
diagnostic tests have shortcomings of being invasive and low accuracy. AIM To explore the …