Glycoconjugates: synthesis, functional studies, and therapeutic developments
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
Synthetic carbohydrate-based vaccines: challenges and opportunities
R Mettu, CY Chen, CY Wu - Journal of Biomedical Science, 2020 - Springer
Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been
extremely successful in preventing bacterial infections. The glycan antigens for the …
extremely successful in preventing bacterial infections. The glycan antigens for the …
Development in the concept of bacterial polysaccharide repeating unit-based antibacterial conjugate vaccines
R Rohokale, Z Guo - ACS infectious diseases, 2023 - ACS Publications
The surface of cells is coated with a dense layer of glycans, known as the cell glycocalyx.
The complex glycans in the glycocalyx are involved in various biological events, such as …
The complex glycans in the glycocalyx are involved in various biological events, such as …
Controlled human infection models to accelerate vaccine development
RKM Choy, AL Bourgeois… - Clinical Microbiology …, 2022 - Am Soc Microbiol
The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
[HTML][HTML] A phase 3, multicenter, randomized, double-blind, active-comparator-controlled study to evaluate the safety, tolerability, and immunogenicity of a 4-dose …
Background Pneumococcal disease (PD) remains a major health concern with considerable
morbidity and mortality in children. Currently licensed pneumococcal conjugate vaccines …
morbidity and mortality in children. Currently licensed pneumococcal conjugate vaccines …
Lignocellulosic biomass-based glycoconjugates for diverse biotechnological applications
CER Reis, TS Milessi, MDN Ramos, AK Singh… - Biotechnology …, 2023 - Elsevier
Glycoconjugates are the ubiquitous components of mammalian cells, mainly synthesized by
covalent bonds of carbohydrates to other biomolecules such as proteins and lipids, with a …
covalent bonds of carbohydrates to other biomolecules such as proteins and lipids, with a …
[HTML][HTML] A phase II trial of safety, tolerability and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, compared with 13-valent pneumococcal …
HL Platt, D Greenberg, B Tapiero… - The Pediatric …, 2020 - journals.lww.com
Background: Pneumococcal disease remains a public health priority worldwide. This phase
2 study (V114-008; NCT02987972; EudraCT 2016-001117-25) compared safety and …
2 study (V114-008; NCT02987972; EudraCT 2016-001117-25) compared safety and …
Pneumococcal vaccines: past findings, present work, and future strategies
The importance of Streptococcus pneumoniae has been well established. These bacteria
can colonize infants and adults without symptoms, but in some cases can spread, invade …
can colonize infants and adults without symptoms, but in some cases can spread, invade …
[HTML][HTML] Safety, tolerability, and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, followed by sequential PPSV23 vaccination in healthy adults …
Background Streptococcus pneumoniae causes pneumococcal disease, and older adults
are at an increased risk. Sequential vaccination of 13-valent pneumococcal conjugate …
are at an increased risk. Sequential vaccination of 13-valent pneumococcal conjugate …
Safety, tolerability, and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, administered concomitantly with influenza vaccine in healthy adults …
R Severance, H Schwartz, R Dagan… - Human Vaccines & …, 2022 - Taylor & Francis
Streptococcus pneumoniae and influenza viruses are associated with significant morbidity
and mortality in older adults. Concomitant vaccination against these agents reduces …
and mortality in older adults. Concomitant vaccination against these agents reduces …