[HTML][HTML] Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
From dried bear bile to molecular investigation: a systematic review of the effect of bile acids on cell apoptosis, oxidative stress and inflammation in the brain, across …
F Huang, CM Pariante, A Borsini - Brain, behavior, and immunity, 2022 - Elsevier
Bile acids, mainly ursodeoxycholic acid (UDCA) and its conjugated species
glycoursodeoxycholic acid (GUDCA) and tauroursodeoxycholic acid (TUDCA) have long …
glycoursodeoxycholic acid (GUDCA) and tauroursodeoxycholic acid (TUDCA) have long …
[HTML][HTML] The food additive maltodextrin promotes endoplasmic reticulum stress–driven mucus depletion and exacerbates intestinal inflammation
Background & Aims Food additives, such as emulsifiers, stabilizers, or bulking agents, are
present in the Western diet and their consumption is increasing. However, little is known …
present in the Western diet and their consumption is increasing. However, little is known …
Bile acids as regulatory molecules and potential targets in metabolic diseases
A Xie, C Mai, YZ Zhu, XC Liu, Y Xie - Life Sciences, 2021 - Elsevier
Bile acids are important hydroxylated steroids that are synthesized in the liver from
cholesterol for intestinal absorption of lipids and other fatty-nutrient. They also display …
cholesterol for intestinal absorption of lipids and other fatty-nutrient. They also display …
[HTML][HTML] Roles of bile acids signaling in neuromodulation under physiological and pathological conditions
C Xing, X Huang, D Wang, D Yu, S Hou, H Cui, L Song - Cell & bioscience, 2023 - Springer
Bile acids (BA) are important physiological molecules not only mediating nutrients
absorption and metabolism in peripheral tissues, but exerting neuromodulation effect in the …
absorption and metabolism in peripheral tissues, but exerting neuromodulation effect in the …
Transplantation of tauroursodeoxycholic acid–inducing M2‐phenotype macrophages promotes an anti‐neuroinflammatory effect and functional recovery after spinal …
Objectives In this study, we study the transplantation of tauroursodeoxycholic acid (TUDCA)‐
induced M2‐phenotype (M2) macrophages and their ability to promote anti …
induced M2‐phenotype (M2) macrophages and their ability to promote anti …
Direct injection of hydrogels embedding gold nanoparticles for local therapy after spinal cord injury
In this study, we created a hydrogel composed of glycol chitosan (gC) and oxidized
hyaluronate (oHA). Gold nanoparticles (GNPs) were conjugated with ursodeoxycholic acid …
hyaluronate (oHA). Gold nanoparticles (GNPs) were conjugated with ursodeoxycholic acid …
[HTML][HTML] Bile acids attenuate PKM2 pathway activation in proinflammatory microglia
L Romero-Ramírez, C García-Rama, S Wu, J Mey - Scientific Reports, 2022 - nature.com
Glycolysis is the metabolic pathway that converts glucose into pyruvate. Central nervous
system (CNS) pathologies, such as spinal cord injury (SCI) and ischemia, are accompanied …
system (CNS) pathologies, such as spinal cord injury (SCI) and ischemia, are accompanied …
Generation of bioactive MSC-EVs for bone tissue regeneration by tauroursodeoxycholic acid treatment
KY Cha, W Cho, S Park, J Ahn, H Park, I Baek… - Journal of Controlled …, 2023 - Elsevier
Extracellular vesicles (EVs) are nano-sized carriers that reflect the parent cell's information
and are known to mediate cell-cell communication. In order to overcome the disadvantages …
and are known to mediate cell-cell communication. In order to overcome the disadvantages …
Rapeseed protein-derived ACE inhibitory peptides LY, RALP and GHS show antioxidant and anti-inflammatory effects on spontaneously hypertensive rats
R He, Y Wang, Y Yang, Z Wang, X Ju, J Yuan - Journal of functional foods, 2019 - Elsevier
Food-derived bioactive peptides have received considerable attention as low toxicity
nutrient supplements with multiple physiological activities, such as antioxidant …
nutrient supplements with multiple physiological activities, such as antioxidant …