Physical activity and depression: Towards understanding the antidepressant mechanisms of physical activity

A Kandola, G Ashdown-Franks, J Hendrikse… - Neuroscience & …, 2019 - Elsevier
Physical activity can treat and prevent depressive symptoms, but its antidepressant
mechanisms are yet to be established. In this review, we comprehensively assess key …

Potential mechanisms underlying centralized pain and emerging therapeutic interventions

OC Eller-Smith, AL Nicol… - Frontiers in cellular …, 2018 - frontiersin.org
Centralized pain syndromes are associated with changes within the central nervous system
that amplify peripheral input and/or generate the perception of pain in the absence of a …

Neurobiology of chronic mild stress: parallels to major depression

MN Hill, KGC Hellemans, P Verma, BB Gorzalka… - Neuroscience & …, 2012 - Elsevier
The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an
animal model of depression more than 20 years ago. The foundation of this model was that …

The exercise-glucocorticoid paradox: How exercise is beneficial to cognition, mood, and the brain while increasing glucocorticoid levels

C Chen, S Nakagawa, Y An, K Ito, Y Kitaichi… - Frontiers in …, 2017 - Elsevier
Exercise is known to have beneficial effects on cognition, mood, and the brain. However,
exercise also activates the hypothalamic–pituitary–adrenal axis and increases levels of the …

A meta-regression to examine the relationship between aerobic fitness and cognitive performance

JL Etnier, PM Nowell, DM Landers, BA Sibley - Brain research reviews, 2006 - Elsevier
Many studies have been conducted to test the potentially beneficial effects of physical
activity on cognition. The results of meta-analytic reviews of this literature suggest that there …

Exercise effects on sleep physiology

S Uchida, K Shioda, Y Morita, C Kubota… - Frontiers in …, 2012 - frontiersin.org
This mini-review focuses on the effects of exercise on sleep. In its early days, sleep research
largely focused on central nervous system (CNS) physiology using standardized tabulations …

The use of a running wheel to measure activity in rodents: relationship to energy balance, general activity, and reward

CM Novak, PR Burghardt, JA Levine - Neuroscience & Biobehavioral …, 2012 - Elsevier
Running wheels are commonly employed to measure rodent physical activity in a variety of
contexts, including studies of energy balance and obesity. There is no consensus on the …

Aerobic exercise as a tool to improve hippocampal plasticity and function in humans: practical implications for mental health treatment

A Kandola, J Hendrikse, PJ Lucassen… - Frontiers in human …, 2016 - frontiersin.org
Aerobic exercise (AE) has been widely praised for its potential benefits to cognition and
overall brain and mental health. In particular, AE has a potent impact on promoting the …

Physical exercise and neuroinflammation in major depressive disorder

ZM Ignácio, RS da Silva, ME Plissari, J Quevedo… - Molecular …, 2019 - Springer
Major depressive disorder (MDD) is a prevalent psychiatric disorder associated with varied
prognosis, chronic course, and duration of illness with reduced quality of life. One factor that …

An overview of the beneficial effects of exercise on health and performance

A Kramer - Physical Exercise for Human Health, 2020 - Springer
Life expectancy is steadily increasing in modern societies, and so are noncommunicable
diseases such as cardiovascular diseases, diabetes, obesity, and cancer, accounting for …