Tenecteplase vs. alteplase for treatment of acute ischemic stroke: a systematic review and meta-analysis of randomized trials

H Kobeissi, S Ghozy, B Turfe, C Bilgin… - Frontiers in …, 2023 - frontiersin.org
Background and objectives Several randomized controlled trials (RCTs) have compared
tenecteplase to alteplase for treatment of acute ischemic stroke (AIS). Yet, there is no meta …

European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke

JM Wardlaw, H Chabriat, FE de Leeuw… - European Stroke …, 2024 - journals.sagepub.com
A quarter of ischaemic strokes are lacunar subtype, typically neurologically mild, usually
resulting from intrinsic cerebral small vessel pathology, with risk factor profiles and outcome …

Inducing cavitation within hollow cylindrical radially polarized transducers for intravascular applications

L Gong, AR Wright, K Hynynen, DE Goertz - Ultrasonics, 2024 - Elsevier
Thrombotic occlusions of large blood vessels are increasingly treated with catheter based
mechanical approaches, one of the most prominent being to employ aspiration to extract …

Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial

SB Coutts, S Ankolekar, R Appireddy, JF Arenillas… - The Lancet, 2024 - thelancet.com
Background Individuals with minor ischaemic stroke and intracranial occlusion are at
increased risk of poor outcomes. Intravenous thrombolysis with tenecteplase might improve …

Tenecteplase versus alteplase for thrombolysis in patients selected by use of perfusion imaging within 4· 5 h of onset of ischaemic stroke (TASTE): a multicentre …

MW Parsons, V Yogendrakumar, L Churilov… - The Lancet …, 2024 - thelancet.com
Background Intravenous tenecteplase increases reperfusion in patients with salvageable
brain tissue on perfusion imaging and might have advantages over alteplase as a …

Effect of time to thrombolysis on clinical outcomes in patients with acute ischemic stroke treated with tenecteplase compared to alteplase: Analysis from the AcT …

N Singh, MA Almekhlafi, F Bala, A Ademola, SB Coutts… - Stroke, 2023 - Am Heart Assoc
BACKGROUND: The AcT (Alteplase Compared to Tenecteplase) randomized controlled trial
showed that tenecteplase is noninferior to alteplase in treating patients with acute ischemic …

A Randomized Controlled Trial of Tenecteplase Versus Standard of Care for Minor Ischemic Stroke with Proven Occlusion (TEMPO-2): Rational and design of a …

N Singh, CC Kenney, KS Butcher… - … Journal of Stroke, 2024 - journals.sagepub.com
Background: Almost half of acute ischemic stroke patients present with mild symptoms and
there are large practice variations in their treatment globally. Individuals with an intracranial …

Clinical Uncertainty in Large Vessel Occlusion ischemic stroke (CULVO): Does automated perfusion scanning make a difference? Protocol of an intrarater and …

JDB Diestro, R Fahed, A Benomar, AT Omar… - Plos one, 2024 - journals.plos.org
Background Guidelines recommend the use of perfusion computed tomography (CT) to
identify emergent large vessel ischemic stroke (ELVIS) patients who are likely to benefit from …

Optimizing acute stroke treatment process: insights from sub-tasks durations in a prospective observational time and motion study

G Koca, M Kumar, G Gubitz, N Kamal - Frontiers in Neurology, 2023 - frontiersin.org
Background Rapid treatment is critical in managing acute ischemic stroke (AIS) to improve
patient outcomes. Various strategies have been used to optimize this treatment process …

Inter-rater reliability of collateral status assessment based on CT angiography: a retrospective study of middle cerebral artery Ischaemic stroke

DD Dolotova, ER Blagosklonova, RS Muslimov… - Journal of Clinical …, 2023 - mdpi.com
The importance of assessing the collateral status (CS) in patients with ischaemic stroke (IS)
has repeatedly been emphasised in clinical guidelines. Various publications offer qualitative …