Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

Broad antibacterial spectrum, high oral bioavailability and excellent tissue penetration
combined with safety and few, yet rare, unwanted effects, have made the quinolones class of …

Bacteriophages (phages), as natural antibacterial agents, are being rediscovered because
of the growing threat of multi-and pan-drug-resistant bacterial pathogens globally. However …

The discovery of crosstalk effects on the renin–angiotensin system (RAS) is limited by the
lack of approaches to quantitatively monitor, in real time, multiple components with subtle …

β Barrel outer membrane proteins (OMPs) cluster into supramolecular assemblies that give
function to the outer membrane (OM) of Gram-negative bacteria. How such assemblies form …

Disinfectants are widely acknowledged for removing microorganisms from the surface of the
objects and transmission media. However, the emergence of disinfectant resistance has …

Gram-negative bacterial pathogens have an outer membrane that restricts entry of
molecules into the cell. Water-filled protein channels in the outer membrane, so-called …

Vitamin B 12, cobalamin, is a cobalt-containing ring-contracted modified tetrapyrrole that
represents one of the most complex small molecules made by nature. In prokaryotes it is …

Nanomaterials, specifically metal nanoclusters (NCs), are gaining attention as a promising
class of antibacterial agents. Metal NCs exhibit antibacterial properties due to their …