Abstract The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human
Cell Atlas, aims to create a comprehensive reference map of cells during development. This …

There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …

Human pluripotent and trophoblast stem cells have been essential alternatives to
blastocysts for understanding early human development 1, 2, 3, 4. However, these simple …

Pluripotent cells emerge as a naive founder population in the blastocyst, acquire capacity for
germline and soma formation, and then undergo lineage priming. Mouse embryonic stem …

Interspecies chimera formation with human pluripotent stem cells (hPSCs) represents a
necessary alternative to evaluate hPSC pluripotency in vivo and might constitute a …

Trophoblast cells play an essential role in the interactions between the fetus and mother.
Mouse trophoblast stem (TS) cells have been derived and used as the best in vitro model for …

Since establishment of the first embryonic stem cells (ESCs), in vitro culture of totipotent cells
functionally and molecularly comparable with in vivo blastomeres with embryonic and …

Our understanding of how human embryos develop before gastrulation, including spatial
self-organization and cell type ontogeny, remains limited by available two-dimensional …

Classic embryological experiments have established that the early mouse embryo develops
via sequential lineage bifurcations. The first segregated lineage is the trophectoderm …

The ontogeny of the human haematopoietic system during fetal development has previously
been characterized mainly through careful microscopic observations. Here we reconstruct a …