Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review

R Margiana, A Markov, AO Zekiy, MU Hamza… - Stem Cell Research & …, 2022 - Springer
The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide
consideration because of their immense potential for immunomodulation and their …

Neuroinflammation and scarring after spinal cord injury: therapeutic roles of MSCs on inflammation and glial scar

QM Pang, SY Chen, QJ Xu, SP Fu, YC Yang… - Frontiers in …, 2021 - frontiersin.org
Transected axons are unable to regenerate after spinal cord injury (SCI). Glial scar is
thought to be responsible for this failure. Regulating the formation of glial scar post-SCI may …

Allicin, an antioxidant and neuroprotective agent, ameliorates cognitive impairment

MS Nadeem, I Kazmi, I Ullah, K Muhammad, F Anwar - Antioxidants, 2021 - mdpi.com
Allicin (diallylthiosulfinate) is a defense molecule produced by cellular contents of garlic
(Allium sativum L.). On tissue damage, the non-proteinogenic amino acid alliin (S …

[HTML][HTML] Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury

Y Rong, Z Wang, P Tang, J Wang, C Ji, J Chang… - Bioactive Materials, 2023 - Elsevier
Spinal cord injury (SCI) is a severe disease of the nervous system that causes irreparable
damage and loss of function, for which no effective treatments are available to date …

Multifunctional integrated nanozymes facilitate spinal cord regeneration by remodeling the extrinsic neural environment

T Xiong, K Yang, T Zhao, H Zhao, X Gao… - Advanced …, 2023 - Wiley Online Library
High levels of reactive oxygen species (ROS) and inflammation create a complicated
extrinsic neural environment that dominates the initial post‐injury period after spinal cord …

Endothelial progenitor cell-derived exosomes promote anti-inflammatory macrophages via SOCS3/JAK2/STAT3 axis and improve the outcome of spinal cord injury

F Yuan, W Peng, Y Yang, J Xu, Y Liu, Y Xie… - Journal of …, 2023 - Springer
Background Macrophage in the spinal cord injury (SCI) area imparts a chronic pro-
inflammation effect that challenges the recovery of SCI. Previously, endothelial progenitor …

[HTML][HTML] Spinal cord injuries

J Bennett, JM Das, PD Emmady - StatPearls [Internet], 2024 - ncbi.nlm.nih.gov
Objectives: Compare the spinal cord syndromes based on pathophysiology and clinical
features. Create a clinically guided diagnostic strategy for an individual with suspected …

Inhibition of A1 astrocytes and activation of A2 astrocytes for the treatment of spinal cord injury

J Wang, C Cheng, Z Liu, Y Lin, L Yang, Z Zhang… - Neurochemical …, 2023 - Springer
Spinal cord injury (SCI) is a serious injury to the central nervous system that causes
significant physical and psychological trauma to the patient. SCI includes primary spinal …

[HTML][HTML] The application of 3D-bioprinted scaffolds for neuronal regeneration after traumatic spinal cord injury–A systematic review of preclinical in vivo studies

M Szymoniuk, M Mazurek, A Dryla, P Kamieniak - Experimental Neurology, 2023 - Elsevier
Background The implantation of 3D-bioprinted scaffolds represents a promising therapeutic
approach for traumatic Spinal Cord Injury (SCI), currently investigating in preclinical in vivo …

Sustained delivery of neurotrophic factors to treat spinal cord injury

A Muheremu, L Shu, J Liang, A Aili… - Translational …, 2021 - degruyter.com
Acute spinal cord injury (SCI) is a devastating condition that results in tremendous physical
and psychological harm and a series of socioeconomic problems. Although neurons in the …