METTL5-mediated 18S rRNA m6A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression
Z Dai, W Zhu, Y Hou, X Zhang, X Ren, K Lei, J Liao… - Molecular Therapy, 2023 - cell.com
Intrahepatic cholangiocarcinoma (ICC) is a deadly cancer with rapid tumor progression.
While hyperactive mRNA translation caused by mis-regulated mRNA or tRNA modifications …
While hyperactive mRNA translation caused by mis-regulated mRNA or tRNA modifications …
The role of RNA G‐quadruplexes in human diseases and therapeutic strategies
P Kharel, S Balaratnam, N Beals… - Wiley Interdisciplinary …, 2020 - Wiley Online Library
G‐quadruplexes (GQs) are four‐stranded secondary structures formed by G‐rich nucleic
acid sequence (s). DNA GQs are present abundantly in the genome and affect a wide range …
acid sequence (s). DNA GQs are present abundantly in the genome and affect a wide range …
How to untie G-quadruplex knots and why?
P Lejault, J Mitteaux, FR Sperti, D Monchaud - Cell chemical biology, 2021 - cell.com
For over two decades, the prime objective of the chemical biology community studying G-
quadruplexes (G4s) has been to use chemicals to interact with and stabilize G4s in cells to …
quadruplexes (G4s) has been to use chemicals to interact with and stabilize G4s in cells to …
Chemical-biology approaches to probe DNA and RNA G-quadruplex structures in the genome
F Raguseo, S Chowdhury, A Minard… - Chemical …, 2020 - pubs.rsc.org
G-quadruplexes are nucleic acids secondary structures that can be formed in guanine-rich
sequences. More than 30 years ago, their formation was first observed in telomeric DNA …
sequences. More than 30 years ago, their formation was first observed in telomeric DNA …
Mechanistic insights into the ligand-induced unfolding of an RNA G-quadruplex
S Haldar, Y Zhang, Y Xia, B Islam, S Liu… - Journal of the …, 2022 - ACS Publications
The cationic porphyrin TMPyP4 is a well-established DNA G-quadruplex (G4) binding ligand
that can stabilize different topologies via multiple binding modes. However, TMPyP4 can …
that can stabilize different topologies via multiple binding modes. However, TMPyP4 can …
The molecular structure of long non-coding RNAs: emerging patterns and functional implications
Long non-coding RNAs (lncRNAs) are recently-discovered transcripts that regulate vital
cellular processes and are crucially connected to diseases. Despite their unprecedented …
cellular processes and are crucially connected to diseases. Despite their unprecedented …
Stability prediction of canonical and non-canonical structures of nucleic acids in various molecular environments and cells
S Takahashi, N Sugimoto - Chemical Society Reviews, 2020 - pubs.rsc.org
Nucleic acids (DNA and RNA) dynamically fold and unfold to exert their functions in cells.
These folding and unfolding behaviours are also the basis for various technical applications …
These folding and unfolding behaviours are also the basis for various technical applications …
G-quadruplex-based fluorescent turn-on ligands and aptamers: from development to applications
Guanine (G)-quadruplexes (G4s) are unique nucleic acid structures that are formed by
stacked G-tetrads in G-rich DNA or RNA sequences. G4s have been reported to play …
stacked G-tetrads in G-rich DNA or RNA sequences. G4s have been reported to play …
hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma
P Herviou, M Le Bras, L Dumas, C Hieblot… - Nature …, 2020 - nature.com
Abstract RNA G-quadruplexes (RG4s) are four-stranded structures known to control mRNA
translation of cancer relevant genes. RG4 formation is pervasive in vitro but not in cellulo …
translation of cancer relevant genes. RG4 formation is pervasive in vitro but not in cellulo …
rG4detector, a novel RNA G-quadruplex predictor, uncovers their impact on stress granule formation
M Turner, YM Danino, M Barshai… - Nucleic acids …, 2022 - academic.oup.com
RNA G-quadruplexes (rG4s) are RNA secondary structures, which are formed by guanine-
rich sequences and have important cellular functions. Existing computational tools for rG4 …
rich sequences and have important cellular functions. Existing computational tools for rG4 …