Podocytopathies
Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …
How many cell types are in the kidney and what do they do?
The kidney maintains electrolyte, water, and acid-base balance, eliminates foreign and
waste compounds, regulates blood pressure, and secretes hormones. There are at least 16 …
waste compounds, regulates blood pressure, and secretes hormones. There are at least 16 …
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …
dysfunction is poorly understood. In the present study, we define the genetic association with …
Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration
The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …
Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury
Y Kirita, H Wu, K Uchimura… - Proceedings of the …, 2020 - National Acad Sciences
After acute kidney injury (AKI), patients either recover or alternatively develop fibrosis and
chronic kidney disease. Interactions between injured epithelia, stroma, and inflammatory …
chronic kidney disease. Interactions between injured epithelia, stroma, and inflammatory …
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy
IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …
Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis
Fibrosis is the final common pathway leading to end-stage renal failure. By analyzing the
kidneys of patients and animal models with fibrosis, we observed a significant mitochondrial …
kidneys of patients and animal models with fibrosis, we observed a significant mitochondrial …
Epigenetics and epigenomics in diabetic kidney disease and metabolic memory
M Kato, R Natarajan - Nature Reviews Nephrology, 2019 - nature.com
The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …
complication of diabetes mellitus, are influenced by both genetic and environmental factors …
Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
A comprehensive map of mRNAs and their isoforms across all 14 renal tubule segments of mouse
L Chen, CL Chou, MA Knepper - Journal of the American Society …, 2021 - journals.lww.com
Background The repertoire of protein expression along the renal tubule depends both on
regulation of transcription and regulation of alternative splicing that can generate multiple …
regulation of transcription and regulation of alternative splicing that can generate multiple …