Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine
serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as …

Abstract Development of resistance to chemotherapy in cancer continues to be a major
challenge in cancer management. Ferroptosis, a unique type of cell death, is mechanistically …

Background Bladder cancer (BLCA) is the most common malignancy of the urinary tract. On
the other hand, disulfidptosis, a mechanism of disulfide stress-induced cell death, is closely …

Death is the inevitable fate of all living organisms, whether at the individual or cellular level.
For a long time, cell death was believed to be an undesirable but unavoidable final outcome …

Abstract Background/Aim Colorectal cancer (CRC), is characterized by aberrant microRNA
(miRNA) expression during their development and progression. Recently, miR-509–5p's …

The expression of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) is
markedly increased in many forms of cancer, including colorectal, ovarian, lung, breast and …

Parkinson disease (PD) is the second-most common neurodegenerative disease. The
characteristic pathology of progressive dopaminergic neuronal loss in people with PD is …

Prostate cancer is the second most common malignancy in men worldwide. Prostate cancer
can be treated by surgery, radiotherapy and hormone therapy. The latter, in the form of …

Here, we show that the tumor suppressor phosphatase and tensin homolog deleted from
chromosome 10 (PTEN) sensitizes cells to ferroptosis, an iron-dependent form of cell death …

Alterations of redox homeostasis leads to a condition of resilience known as hormesis that is
due to the activation of redox-sensitive pathways stimulating cell proliferation, growth …