A comprehensive review on the role of the gut microbiome in human neurological disorders

SG Sorboni, HS Moghaddam… - Clinical microbiology …, 2022 - Am Soc Microbiol
The human body is full of an extensive number of commensal microbes, consisting of
bacteria, viruses, and fungi, collectively termed the human microbiome. The initial …

[HTML][HTML] Prevalence of depression and anxiety in the different clinical forms of multiple sclerosis and associations with disability: A systematic review and meta …

DS Peres, P Rodrigues, FT Viero, JM Frare… - Brain, behavior, & …, 2022 - Elsevier
Multiple sclerosis (MS) is a chronic neurodegenerative and autoimmune disease. Motor,
sensory and cognitive deficits in MS are commonly accompanied by psychiatric disorders …

Role of gut microbiota in neurological disorders and its therapeutic significance

P Tiwari, R Dwivedi, M Bansal, M Tripathi… - Journal of Clinical …, 2023 - mdpi.com
In humans, the gut microbiota (GM) are known to play a significant role in the metabolism of
nutrients and drugs, immunomodulation, and pathogen defense by inhabiting the …

The role of miRNAs in multiple sclerosis pathogenesis, diagnosis, and therapeutic resistance

AS Doghish, O Elazazy, HH Mohamed… - … -Research and Practice, 2023 - Elsevier
In recent years, microRNAs (miRNAs) have gained increased attention from researchers
around the globe. Although it is twenty nucleotides long, it can modulate several gene …

Role of tumor necrosis factor-alpha in the central nervous system: A focus on autoimmune disorders

N Gonzalez Caldito - Frontiers in Immunology, 2023 - frontiersin.org
Tumor necrosis factor-alpha (TNF-α) is a pleiotropic immune cytokine that belongs to the
TNF superfamily of receptor ligands. The cytokine exists as either a transmembrane or a …

Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability

B Pál - Cellular and Molecular Life Sciences, 2018 - Springer
Glutamate is the most abundant neurotransmitter of the central nervous system, as the
majority of neurons use glutamate as neurotransmitter. It is also well known that this …

Targeting nuclear receptors in neurodegeneration and neuroinflammation

S Willems, D Zaienne, D Merk - Journal of medicinal chemistry, 2021 - ACS Publications
Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …

Dimethyl fumarate treatment in multiple sclerosis: Recent advances in clinical and immunological studies

GM Diaz, R Hupperts, J Fraussen, V Somers - Autoimmunity reviews, 2018 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous
system (CNS) in which demyelination and neurodegeneration occurs. The immune system …

Impact of the COVID-19 pandemic on persons with multiple sclerosis: Early findings from a survey on disruptions in care and self-reported outcomes

T Manacorda, P Bandiera, F Terzuoli… - Journal of health …, 2021 - journals.sagepub.com
Objective To describe the disruptions in care experienced by persons with Multiple Sclerosis
in Italy due to the COVID-19 pandemic and the self-reported impact on their health and …

[HTML][HTML] An overview of the history, pathophysiology, and pharmacological interventions of multiple sclerosis

IM Dighriri, AA Aldalbahi, F Albeladi, AA Tahiri… - Cureus, 2023 - ncbi.nlm.nih.gov
Multiple sclerosis (MS) is an immune-inflammatory disease that attacks and damages
myelinated axons in the central nervous system (CNS) and causes nontraumatic …