The kidney harbours different types of endothelia, each with specific structural and functional
characteristics. The glomerular endothelium, which is highly fenestrated and covered by a …

Endothelial activation and dysfunction is an important contributor to atherosclerosis,
cardiovascular diseases and cardiorenal syndrome. Endothelial dysfunction is also linked …

Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

Many types of kidney injury induce inflammation as a protective response. However,
unresolved inflammation promotes progressive renal fibrosis, which can culminate in end …

Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here,
we review the major components of this dynamic process, which involves hemodynamic …

Since the discovery in the 1980s that nitric oxide (NO) is in fact the elusive endothelium-
derived relaxing factor, it has become evident that NO is not only a major cardiovascular …

Endothelial cells (ECs) are a heterogeneous population that fulfills many physiological
processes. ECs also actively participate in both innate and adaptive immune responses …

Ischemia/reperfusion is a common cause of acute kidney injury (AKI). However, mechanisms
underlying the sudden loss in kidney function and tissue injury remain to be fully elucidated …

Albuminuria is commonly used as a marker of kidney disease progression, but some
evidence suggests that albuminuria also contributes to disease progression by inducing …

Changes in endothelial glycocalyx are one of the earliest changes in development of
cardiovascular disease. The endothelial glycocalyx is both an important biological modifier …