[HTML][HTML] PPAR-γ modulators as current and potential cancer treatments

T Chi, M Wang, X Wang, K Yang, F Xie, Z Liao… - Frontiers in …, 2021 - frontiersin.org
Worldwide, cancer has become one of the leading causes of mortality. Peroxisome
Proliferator-Activated Receptors (PPARs) is a family of critical sensors of lipids as well as …

Calcium signaling and epigenetics: A key point to understand carcinogenesis

E Izquierdo-Torres, A Hernandez-Oliveras… - Cell Calcium, 2020 - Elsevier
Abstract Calcium (Ca 2+) signaling controls a wide range of cellular processes, including the
hallmarks of cancer. The Ca 2+ signaling system encompasses several types of proteins …

Structure and interactions of the endogenous human Commander complex

S Laulumaa, EP Kumpula, JT Huiskonen… - Nature Structural & …, 2024 - nature.com
The Commander complex, a 16-protein assembly, plays multiple roles in cell homeostasis,
cell cycle and immune response. It consists of copper-metabolism Murr1 domain proteins …

Transcriptional analysis of the expression, prognostic value and immune infiltration activities of the COMMD protein family in hepatocellular carcinoma

X Wang, S He, X Zheng, S Huang, H Chen, H Chen… - BMC cancer, 2021 - Springer
Background The copper metabolism MURR1 domain (COMMD) protein family involved in
tumor development and progression in several types of human cancer, but little is known …

[PDF][PDF] COMMD5/HCaRG hooks endosomes on cytoskeleton and coordinates EGFR trafficking

CG Campion, K Zaoui, T Verissimo, S Cossette… - Cell reports, 2018 - cell.com
COMMD5/HCaRG is involved in tissue repair, and its low expression is associated with
tumorigenicity. Cell growth, migration, and differentiation are controlled by COMMD5. We …

miR372 promotes progression of liver cancer cells by upregulating erbB-2 through enhancement of YB-1

Z Lin, Y Lu, Q Meng, C Wang, X Li, Y Yang… - … Therapy-Nucleic Acids, 2018 - cell.com
MicroRNAs are known to be involved in carcinogenesis. Recently, microRNA-372 (miR372)
has been proven to play a substantial role in several human cancers, but its functions in liver …

[HTML][HTML] Investigating the association between COMMD3 expression and the prognosis of hepatocellular carcinoma

W Cheng, Z Cheng, C Zhang, L Weng, D Xing… - Journal of …, 2022 - ncbi.nlm.nih.gov
Abstract The Copper Metabolism MURR1 Domain (COMMD) family proteins are known to
play roles in promoting or inhibiting the proliferation, migration and invasion of tumor cells …

COMMD3 Expression Affects Angiogenesis through the HIF1α/VEGF/NF‐κB Signaling Pathway in Hepatocellular Carcinoma In Vitro and In Vivo

T Zhu, X Peng, Z Cheng, X Gong, D Xing… - Oxidative Medicine …, 2022 - Wiley Online Library
Background. High expression of copper metabolizing MURR1 domain (COMMD3) is
significantly correlated with poor prognosis in hepatocellular carcinoma (HCC) patients …

Human Autoantigen Atlas: Searching for the Hallmarks of Autoantigens

D Wang, D Yang, L Yang, L Diao, Y Zhang… - Journal of Proteome …, 2023 - ACS Publications
Understanding autoimmunity to endogenous proteins is crucial in diagnosing and treating
autoimmune diseases. In this work, we developed a user-friendly AAgAtlas portal …

[HTML][HTML] Decoding Gastric Cancer: Machine Learning Insights Into the Significance of COMMDs Family in Immunotherapy and Diagnosis

R Wan, L Pan, Q Wang, G Shen, RN Guo, Y Qin… - Journal of …, 2024 - ncbi.nlm.nih.gov
Copper, an indispensable trace element for the human body, serves not only as a crucial
auxiliary factor in redox reactions within the organism but also as a significant constituent of …