Aging refers to the gradual physiological changes that occur in an organism after reaching
adulthood, resulting in senescence and a decline in biological functions, ultimately leading …

The accumulation and misfolding of α‐synuclein (α‐syn) represent the main pathological
hallmark of PD. Overexpression of α‐syn and failure of cellular protein degradation systems …

Mitochondrial dysfunction is involved in aging and multiple degenerative diseases, including
intervertebral disc degeneration (IVDD) and osteoarthritis (OA). Thus, the maintenance of …

Aims: Cisplatin, an anticancer drug, always leads to nephrotoxicity by causing mitochondrial
dysfunction. As a major mechanism for cellular self-degradation, autophagy has been …

Spinal cord injury (SCI) is the main cause of severe damage to the central nervous system
and leads to irreversible tissue loss and neurological dysfunction. Ferroptosis is a cell death …

Induction of autophagy is a prospective approach to the treatment of neurodegeneration. In
the recent decade, trehalose attracted special attention. It is an autophagy inducer with …

Stroke is considered a leading cause of mortality and neurological disability, which puts a
huge burden on individuals and the community. To date, effective therapy for stroke has …

Parkinson's disease (PD) is a progressive movement disorder resulting primarily from loss of
nigrostriatal dopaminergic neurons. PD is characterized by the accumulation of protein …

Autophagy modulation is considered to be a promising programmed cell death mechanism
to prevent and cure a great number of disorders and diseases. The crucial step in designing …

The neuroprotective effect of autophagy activation by rapamycin and trehalose was studied
in a mouse model of Parkinson's disease (PD) induced by neurotoxin 1-methyl-4-phenyl-1 …