Advances in plant polysaccharides as antiaging agents: Effects and signaling mechanisms
Aging refers to the gradual physiological changes that occur in an organism after reaching
adulthood, resulting in senescence and a decline in biological functions, ultimately leading …
adulthood, resulting in senescence and a decline in biological functions, ultimately leading …
The vicious cycle between α‐synuclein aggregation and autophagic‐lysosomal dysfunction
G Bellomo, S Paciotti, L Gatticchi… - Movement …, 2020 - Wiley Online Library
The accumulation and misfolding of α‐synuclein (α‐syn) represent the main pathological
hallmark of PD. Overexpression of α‐syn and failure of cellular protein degradation systems …
hallmark of PD. Overexpression of α‐syn and failure of cellular protein degradation systems …
Mitophagy in degenerative joint diseases
K Sun, X Jing, J Guo, X Yao, F Guo - Autophagy, 2021 - Taylor & Francis
Mitochondrial dysfunction is involved in aging and multiple degenerative diseases, including
intervertebral disc degeneration (IVDD) and osteoarthritis (OA). Thus, the maintenance of …
intervertebral disc degeneration (IVDD) and osteoarthritis (OA). Thus, the maintenance of …
[HTML][HTML] Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury
L Zhu, Y Yuan, L Yuan, L Li, F Liu, J Liu, Y Chen… - Theranostics, 2020 - ncbi.nlm.nih.gov
Aims: Cisplatin, an anticancer drug, always leads to nephrotoxicity by causing mitochondrial
dysfunction. As a major mechanism for cellular self-degradation, autophagy has been …
dysfunction. As a major mechanism for cellular self-degradation, autophagy has been …
[HTML][HTML] Trehalose inhibits ferroptosis via NRF2/HO-1 pathway and promotes functional recovery in mice with spinal cord injury
F Gong, T Ge, J Liu, J Xiao, X Wu, H Wang… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) is the main cause of severe damage to the central nervous system
and leads to irreversible tissue loss and neurological dysfunction. Ferroptosis is a cell death …
and leads to irreversible tissue loss and neurological dysfunction. Ferroptosis is a cell death …
Disaccharide trehalose in experimental therapies for neurodegenerative disorders: Molecular targets and translational potential
AB Pupyshev, TP Klyushnik, AA Akopyan… - Pharmacological …, 2022 - Elsevier
Induction of autophagy is a prospective approach to the treatment of neurodegeneration. In
the recent decade, trehalose attracted special attention. It is an autophagy inducer with …
the recent decade, trehalose attracted special attention. It is an autophagy inducer with …
[HTML][HTML] Natural compounds modulate the autophagy with potential implication of stroke
Stroke is considered a leading cause of mortality and neurological disability, which puts a
huge burden on individuals and the community. To date, effective therapy for stroke has …
huge burden on individuals and the community. To date, effective therapy for stroke has …
Trehalose as a promising therapeutic candidate for the treatment of Parkinson's disease
M Khalifeh, GE Barreto… - British journal of …, 2019 - Wiley Online Library
Parkinson's disease (PD) is a progressive movement disorder resulting primarily from loss of
nigrostriatal dopaminergic neurons. PD is characterized by the accumulation of protein …
nigrostriatal dopaminergic neurons. PD is characterized by the accumulation of protein …
Autophagy modulators: mechanistic aspects and drug delivery systems
Autophagy modulation is considered to be a promising programmed cell death mechanism
to prevent and cure a great number of disorders and diseases. The crucial step in designing …
to prevent and cure a great number of disorders and diseases. The crucial step in designing …
Therapeutic activation of autophagy by combined treatment with rapamycin and trehalose in a mouse MPTP-induced model of Parkinson's disease
AB Pupyshev, MA Tikhonova, AA Akopyan… - Pharmacology …, 2019 - Elsevier
The neuroprotective effect of autophagy activation by rapamycin and trehalose was studied
in a mouse model of Parkinson's disease (PD) induced by neurotoxin 1-methyl-4-phenyl-1 …
in a mouse model of Parkinson's disease (PD) induced by neurotoxin 1-methyl-4-phenyl-1 …