Myocardial infarction (MI) is the leading cause of death and morbidity worldwide, with an
incidence relatively high in developed countries and rapidly growing in developing …

After an ischemic injury, the heart undergoes a complex process of structural and functional
remodeling that involves several steps, including inflammatory and fibrotic responses. In this …

Exercise training has been reported to alleviate cardiac fibrosis and ameliorate heart
dysfunction after myocardial infarction (MI), but the molecular mechanism is still not fully …

Background Excessive myocardial fibrosis is the pathological basis of heart failure following
myocardial infarction (MI). Although calycosin improves cardiac function, its effect on cardiac …

Acute myocardial infarction (AMI) is a severe ischemic disease with high morbidity and
mortality worldwide. Maladaptive cardiac remodeling is a series of abnormalities in cardiac …

Background The use of percutaneous coronary intervention (PCI) in patients with ST‐
segment elevation myocardial infarction (STEMI) is associated with a mortality rate of 5 …

Metabolic syndrome (MetS) is a cluster of factors that increase the risk of developing
diabetes, stroke, and heart failure. The pathophysiology of injury by ischemia/reperfusion …

Tissue engineering combines cell biology and material science to construct tissues or
organs for disease modeling, drug testing, and regenerative medicine. The cell sheet is a …

Immunophilins are a family of proteins encompassing FK506-binding proteins (FKBPs) and
cyclophilins (Cyps). FKBPs and Cyps exert peptidyl-prolyl cis-trans isomerase (PPIase) …

It is noteworthy that prolonged cardiac structural changes and excessive fibrosis caused by
myocardial infarction (MI) seriously interfere with the treatment of heart failure in clinical …