Aims To evaluate congenital anomaly (CA)‐medication exposure associations produced by
the new EUROmediCAT signal detection system and determine which require further …

Embryonic vascular disruption is an important adverse outcome pathway (AOP) as chemical
disruption of cardiovascular development induces broad prenatal defects. High throughput …

Teratology, the study of congenital anomalies and their causative factors intersects with
developmental and reproductive toxicology, employing innovative methodologies …

Vasculogenesis and angiogenesis are the processes by which new blood vessels are
formed. We have developed a serum-free human adipose stromal cell and umbilical cord …

Background Because pregnant women are often excluded from clinical trials, there is still
very limited information about the risk and safety of prescription drugs during pregnancy …

Background Valproic acid (VPA) is an antiepileptic and anti-migraine prophylactic drug. VPA
exhibits two severe side effects, namely acute liver toxicity and teratogenicity. These side …

SWOT analysis was used to gain insights and perspectives into the revision of the ICH S5
(R2) guideline on detection of toxicity to reproduction for medicinal products. The current …

Embryonic zebrafish represent a useful test system to screen substances for their ability to
perturb development. The exposure scenarios, endpoints captured, and data analysis vary …

Birth defects may originate through multiple mechanisms and may be caused by a variety of
possible exposures, including medications in early pregnancy. In this review, we describe …

A literature review was performed to collect information on the role of pharmacogenetics in
six proposed teratogenic mechanisms associated with drug use during pregnancy: folate …