Cell-mediated immune response to human papillomavirus infection

M Scott, M Nakagawa, AB Moscicki - Clinical Diagnostic …, 2001 - Am Soc Microbiol
Acquisition of human papillomavirus (HPV) results in an infection of variable duration which
may or may not be associated with clinically apparent lesions. Lesions caused by skintropic …

Advances in peptide-based human papillomavirus therapeutic vaccines

TY Liu, WM Hussein, I Toth… - Current topics in …, 2012 - ingentaconnect.com
Cervical cancer is the second leading cause of cancer in women worldwide. Human
papillomavirus (HPV) is responsible for all cases of cervical cancer. Commercial …

A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive

L Muderspach, S Wilczynski, L Roman, L Bade… - Clinical Cancer …, 2000 - AACR
Eighteen women with high-grade cervical or vulvar intraepithelial neoplasia who were
positive for human papillomavirus (HPV) 16 and were HLA-A2 positive were treated with …

Computer‐assisted analysis of molecular mimicry between human papillomavirus 16 E7 oncoprotein and human protein sequences

C Natale, T Giannini, A Lucchese… - Immunology and cell …, 2000 - Wiley Online Library
The immunology of human papillomavirus (HPV) infections has peculiar characteristics. The
long latency for cervical cancer development after primary viral infection suggests …

Multiantigenic peptide–polymer conjugates as therapeutic vaccines against cervical cancer

WM Hussein, TY Liu, Z Jia, NAJ McMillan… - Bioorganic & medicinal …, 2016 - Elsevier
Immunotherapy is one of the most promising strategies for the treatment of cancer. Human
papillomavirus (HPV) is responsible for virtually all cases of cervical cancer. The main …

Development of HPV vaccines for HPV-associated head and neck squamous cell carcinoma

K Devaraj, ML Gillison, TC Wu - Critical Reviews in Oral …, 2003 - journals.sagepub.com
High-risk genotypes of the human papillomavirus (HPV), particularly HPV type 16, are found
in a distinct subset of head and neck squamous cell carcinomas (HNSCC). Thus, these HPV …

HLA class I binding promiscuity of the CD8 T-cell epitopes of human papillomavirus type 16 E6 protein

M Nakagawa, KH Kim, TM Gillam… - Journal of virology, 2007 - Am Soc Microbiol
One of the critical steps in the progression to cervical cancer appears to be the
establishment of persistent human papillomavirus (HPV) infection. We have demonstrated …

Double conjugation strategy to incorporate lipid adjuvants into multiantigenic vaccines

WM Hussein, TY Liu, P Maruthayanar, S Mukaida… - Chemical …, 2016 - pubs.rsc.org
Conjugation of multiple peptides by their N-termini is a promising technique to produce
branched multiantigenic vaccines. We established a double conjugation strategy that …

Intranasal immunization with synthetic peptides corresponding to the E6 and E7 oncoproteins of human papillomavirus type 16 induces systemic and mucosal cellular …

PR Manuri, B Nehete, PN Nehete, R Reisenauer… - Vaccine, 2007 - Elsevier
The E6 and E7 oncoproteins of the high-risk HPV type16 represent ideal targets for HPV
vaccine development, they being consistently expressed in cervical cancer lesions. Since …

Preventive and therapeutic vaccines for human papillomavirus-associated cervical cancers

M Ling, M Kanayama, R Roden, TC Wu - Journal of biomedical science, 2000 - karger.com
Abstract 'High risk'genotypes of the human papillomavirus (HPV), particularly HPV type 16,
are the primary etiologic agent of cervical cancer. Thus, HPV-associated cervical …