[HTML][HTML] Immunopathology of chronic hepatitis B infection: role of innate and adaptive immune response in disease progression

A Khanam, JV Chua, S Kottilil - International Journal of Molecular …, 2021 - mdpi.com
More than 250 million people are living with chronic hepatitis B despite the availability of
highly effective vaccines and oral antivirals. Although innate and adaptive immune cells play …

Hepatitis B surface antigen seroclearance: immune mechanisms, clinical impact, importance for drug development

I Tout, D Loureiro, A Mansouri, V Soumelis, N Boyer… - Journal of …, 2020 - Elsevier
HBsAg seroclearance occurs rarely in the natural history of chronic hepatitis B (CHB)
infection and is associated with improved clinical outcomes. Many factors are associated …

[HTML][HTML] Cytokines and chemokines in HBV infection

S Zhong, T Zhang, L Tang, Y Li - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Chronic hepatitis B virus (HBV) infection remains a leading cause of hepatic inflammation
and damage. The pathogenesis of chronic hepatitis B (CHB) infection is predominantly …

[HTML][HTML] The role of interleukins in HBV infection: A narrative review

K Dimitriadis, S Katelani, M Pappa… - Journal of Personalized …, 2023 - mdpi.com
Hepatitis B virus (HBV) infection is a worldwide medical issue with significant morbidity and
mortality, as it is the main cause of chronic liver disease and hepatocellular carcinoma …

Association of cytokines with hepatitis B virus and its antigen

M Li, Q Chen, L Zhang, H Lu, F Sun… - Journal of Medical …, 2020 - Wiley Online Library
To investigate the characteristics of cytokines in patients with different HBV infection status
and their correlation with HBV DNA, HBsAg, and HBeAg levels. Peripheral blood samples …

Programmed death 1 expressing CD8+CXCR5+ follicular T cells constitute effector rather than exhaustive phenotype in patients with chronic hepatitis B

A Khanam, LSY Tang, S Kottilil - Hepatology, 2022 - Wiley Online Library
Abstract Background and Aims Classical CD8 T cells are implicated for protective and
pathogenic roles in chronic hepatitis B (CHB) infection. Recently, a subset of CD8 T cells …

[HTML][HTML] Characterization of T cell immunity in chronic hepatitis B virus-infected mothers with postpartum alanine transaminase flare

M Huang, Y Gao, X Yin, X Zhang, Y Hao, J Hu… - BMC Infectious …, 2021 - Springer
Background Postpartum alanine transaminase (ALT) flares occur frequently in chronic
hepatitis B virus (HBV)-infected mothers with antepartum antiviral therapy (AVT). We aimed …

[HTML][HTML] Hepatitis B and circadian rhythm of the liver

I Skrlec, J Talapko - World journal of gastroenterology, 2022 - ncbi.nlm.nih.gov
The circadian rhythm in humans is determined by the central clock located in the
hypothalamus's suprachiasmatic nucleus, and it synchronizes the peripheral clocks in other …

[HTML][HTML] HBeAg is indispensable for inducing liver sinusoidal endothelial cell activation by hepatitis B virus

X Xie, J Luo, D Zhu, W Zhou, X Yang, X Feng… - Frontiers in Cellular …, 2022 - frontiersin.org
Background and Aims Liver sinusoidal endothelial cells (LSECs) serve as sentinel cells to
detect microbial infection and actively contribute to regulating immune responses for …

[HTML][HTML] Chronic hepatitis B infection is associated with increased molecular degree of inflammatory perturbation in peripheral blood

CL Vinhaes, LAB Cruz, RC Menezes, TA Carmo… - Viruses, 2020 - mdpi.com
Hepatitis B virus (HBV) infection remains a major public health concern. The interaction
between HBV and the host inflammatory response is an important contributing factor driving …